Antithrombotic treatment patterns in patients with atrial fibrillation in Italy pre- and post-DOACs: the REPAIR study

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Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation

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Published on: February 26, 2013

Luca D Esposti¹, Jean-Baptiste Briere², Kevin Bowrin²

¹CliCon Srl, Health Economics and Outcomes Research, Ravenna, Italy.

Future Cardiology

|January 22, 2019

Abstract

Aim:

To evaluate antithrombotic treatment patterns in patients in Italy with nonvalvular atrial fibrillation (NVAF) before and after direct oral anticoagulants (DOACs) were approved.

Methods:

This analysis included patients with a discharge diagnosis of NVAF in 2010 and 2014, which constituted the pre- and post-DOACs populations, respectively.

Results:

Approximately 90% of patients were eligible for oral anticoagulant (OAC) therapy. Overall use of OACs increased from 38% in 2010 to 45% in 2014; use of antiplatelet therapy decreased from 36 to 25%. Approximately 14% of eligible patients remained untreated.

Conclusion:

Although an improvement in OAC prescription was observed post-DOACs launch, treatment patterns in Italy suggest that a proportion of patients with NVAF are still undertreated or do not receive appropriate therapy.

Keywords:

OAC prescription antithrombotic treatment patterns direct oral anticoagulants nonvalvular atrial fibrillation real-world data

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