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Isolation of Viral Replication Compartment-enriched Sub-nuclear Fractions from Adenovirus-infected Normal Human Cells
Published on: November 12, 2015
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Targeting nuclear proteins for control of viral replication
Wen Meng1, Xiao-Jia Wang1, Hwa-Chain Robert Wang2
1Key Laboratory of Animal Epidemiology of the Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, Beijing, China.
Critical Reviews in Microbiology
|January 22, 2019
Summary
Viruses hijack host nuclear proteins by moving them to the cytoplasm to aid replication. Understanding these viral strategies can lead to new antiviral therapies.
Area of Science:
- Virology
- Cell Biology
- Molecular Biology
Background:
- Viruses are obligate intracellular parasites.
- Viral replication depends on host cell machinery.
Purpose of the Study:
- To review host cell nuclear proteins manipulated by viruses.
- To understand how viruses utilize these proteins for replication.
Main Methods:
- Literature review of viral hijacking of host nuclear proteins.
- Analysis of mechanisms of nucleo-cytoplasmic transport manipulation.
Main Results:
- Viruses induce translocation of nuclear proteins to the cytoplasm.
- Viral strategies include disrupting nuclear import/export and altering nuclear pore complexes.
- Nuclear localization signals (NLS) on proteins are removed or modified.
Conclusions:
- Understanding viral manipulation of nucleo-cytoplasmic transport is key.
- This knowledge can inform the development of novel antiviral agents.
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