Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Indeterminate Structure01:18

Indeterminate Structure

1.5K
Indeterminate structures refer to structures where internal forces and reactions cannot be determined using only the equations of static equilibrium.  Indeterminate structures have more unknown forces and reaction forces than equations of static equilibrium that can be used to determine them. Indeterminate structures are often used in engineering to create complex, efficient, and aesthetically pleasing structures. There are various types of indeterminate structures used in engineering and...
1.5K
Indeterminate Products01:29

Indeterminate Products

52
Indeterminate forms also arise in the evaluation of limits involving products, particularly when one factor approaches zero while the other tends to positive or negative infinity. This situation, commonly described as a zero-times-infinity form, does not have an immediately interpretable outcome. Depending on how the factors behave relative to one another, the limit of such a product may be zero, infinite, or a finite nonzero value.Product Limits and Algebraic RewritingTo analyze limits of this...
52
Statically Indeterminate Problem Solving01:16

Statically Indeterminate Problem Solving

720
Statically indeterminate problems are those where statics alone can not determine the internal forces or reactions. Consider a structure comprising two cylindrical rods made of steel and brass. These rods are joined at point B and restrained by rigid supports at points A and C. Now, the reactions at points A and C and the deflection at point B are to be determined. This rod structure is classified as statically indeterminate as the structure has more supports than are necessary for maintaining...
720
Indeterminate Forms and L’Hôpital’s Rule01:27

Indeterminate Forms and L’Hôpital’s Rule

111
Indeterminate forms occur when evaluating limits leads to expressions that cannot be directly interpreted, such as zero divided by zero or infinity divided by infinity. These results do not describe the true behavior of a function near a given point and instead signal that additional analysis is required. L’Hôpital’s Rule provides a reliable method for resolving such ambiguities by replacing the original functions with their derivatives.Core Idea of L’Hôpital’s...
111
The Thyroid Gland01:23

The Thyroid Gland

7.6K
The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
7.6K
Functions of Thyroid Hormones01:18

Functions of Thyroid Hormones

5.6K
The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
5.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

On the current clinical applicability of artificial intelligence in pathology: An evidence-informed clinical readiness review.

Annals of diagnostic pathology·2026
Same author

Molecular and spatial differences in the tumor microenvironment of high-grade serous ovarian cancers with short versus long-term survival.

Gynecologic oncology·2026
Same author

Combined inhibition of NAD synthesis and C-terminal binding protein cooperatively induces cell death and inhibits growth of high grade serous ovarian carcinoma.

Scientific reports·2025
Same author

SOX9 drives a stem-like transcriptional state and platinum resistance in high-grade serous ovarian cancer.

The Journal of clinical investigation·2025
Same author

Phospho-RPA2 predicts response to platinum and PARP inhibitors in homologous recombination-proficient ovarian cancer.

The Journal of clinical investigation·2025
Same author

An Evaluation Into the Robustness of Grading of Pleural Mesothelioma Outside of Specialist Centres.

APMIS : acta pathologica, microbiologica, et immunologica Scandinavica·2025

Related Experiment Video

Updated: Jan 30, 2026

A Swin Transformer-Based Model for Thyroid Nodule Detection in Ultrasound Images
04:23

A Swin Transformer-Based Model for Thyroid Nodule Detection in Ultrasound Images

Published on: April 21, 2023

2.3K

Update on Molecular Testing for Cytologically Indeterminate Thyroid Nodules.

Shikha Bose1, Wendy Sacks, Ann E Walts

  • 1Cedars-Sinai Medical Center, Los Angeles, CA.

Advances in Anatomic Pathology
|January 22, 2019
PubMed
Summary

Molecular tests help classify indeterminate thyroid nodules. These tests improve accuracy in distinguishing benign from malignant nodules, guiding patient therapy and reducing unnecessary procedures.

More Related Videos

Impression Cytology of the Lid Wiper Area
07:01

Impression Cytology of the Lid Wiper Area

Published on: August 9, 2016

11.0K
Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
04:39

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Published on: March 17, 2023

2.5K

Related Experiment Videos

Last Updated: Jan 30, 2026

A Swin Transformer-Based Model for Thyroid Nodule Detection in Ultrasound Images
04:23

A Swin Transformer-Based Model for Thyroid Nodule Detection in Ultrasound Images

Published on: April 21, 2023

2.3K
Impression Cytology of the Lid Wiper Area
07:01

Impression Cytology of the Lid Wiper Area

Published on: August 9, 2016

11.0K
Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
04:39

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Published on: March 17, 2023

2.5K

Area of Science:

  • Endocrinology
  • Oncology
  • Molecular Diagnostics

Background:

  • Fine needle aspiration biopsy (FNAB) and ultrasonography are standard for thyroid nodule diagnosis.
  • A significant proportion of thyroid nodules (20-30%) are classified as indeterminate, posing a challenge for malignancy risk assessment.

Purpose of the Study:

  • To review the role and performance of molecular tests in triaging indeterminate thyroid nodules.
  • To discuss currently available molecular diagnostic tests and their upgrades for improved accuracy.

Main Methods:

  • Review of commercially available molecular tests for thyroid nodules.
  • Analysis of test performance and post-validation publications.
  • Consideration of factors influencing test efficacy, such as institutional malignancy rates and diagnostic variability.

Main Results:

  • Several molecular tests (Afirma, Thryoseq, RosettaGX Reveal, ThyGenX/ThyraMIR) are available to aid in classifying indeterminate thyroid nodules.
  • Newer test versions aim to enhance accuracy in ruling in or out malignancy.
  • Institutional factors and diagnostic variability impact molecular test performance.

Conclusions:

  • Molecular testing is crucial for refining the management of indeterminate thyroid nodules.
  • Understanding test performance and relevant influencing factors is key for appropriate patient triage and therapy selection.