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Caspase recruitment domains for protein interactions in cellular signaling (Review)

Hyun Ho Park1

  • 1Department of Pharmacy, College of Pharmacy, Chung‑Ang University, Seoul 06974, Republic of Korea.

International Journal of Molecular Medicine
|January 22, 2019
PubMed

Insights

The caspase recruitment domain (CARD) is key in cell signaling and disease. Structural studies reveal how CARD interactions assemble signaling complexes, improving understanding of cellular processes and diseases like cancer.

Area of Science:

  • Molecular Biology
  • Structural Biology
  • Immunology

Background:

  • The caspase recruitment domain (CARD) is a protein interaction module within the death domain (DD) superfamily.
  • The DD superfamily is crucial for apoptosis and immune cell signaling.
  • CARD interactions are implicated in human diseases such as cancer and neurodegenerative disorders.

Purpose of the Study:

  • To review and discuss structural studies of CARDs and their complexes.
  • To elucidate the mechanisms governing the assembly and disassembly of CARD-mediated signaling complexes.
  • To enhance the understanding of cellular signaling processes involving CARDs.

Main Methods:

  • Review of existing structural studies on CARDs.
  • Analysis of CARD-CARD interactions (homo-type and hetero-type).
  • Examination of CARD complexes involved in signaling.

Main Results:

  • Structural insights into various CARDs and their complexes have been summarized.
  • Mechanisms controlling the formation and dissolution of signaling complexes are highlighted.
  • Understanding of CARD-mediated signaling in disease contexts is improved.

Conclusions:

  • Structural studies of CARDs provide critical insights into cellular signaling.
  • The CARD domain's role in assembling signaling complexes is essential for biological processes.
  • Further research on CARDs can advance therapeutic strategies for associated diseases.

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