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Conceptual evolution of renin research.

T Inagami1, M Nakamaru, K Mizuno

  • 1Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232.

Clinical and Experimental Hypertension. Part A, Theory and Practice
|January 1, 1988
PubMed
Summary

Research on renin has evolved significantly since its 1898 discovery. Recent findings reveal renin

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Area of Science:

  • Biochemistry and Molecular Biology
  • Physiology

Background:

  • The discovery of renin in 1898 marked the beginning of extensive research into its physiological roles.
  • Over 90 years, understanding of renin has evolved from its classical role in blood pressure regulation to encompass intracellular functions.

Purpose of the Study:

  • To review the historical evolution of renin research.
  • To highlight the recently discovered intracellular function of renin.
  • To discuss molecular studies on the regulation of renin expression.

Main Methods:

  • Literature review of historical and recent research on renin.
  • Analysis of molecular biological studies on renin expression.
  • Synthesis of findings on intracellular renin and angiotensin II generation.

Main Results:

  • Renin's function has expanded beyond extracellular roles to include intracellular activities.
  • Angiotensin II is generated within renin-containing cells, indicating novel local regulatory mechanisms.
  • Molecular studies are elucidating the complex regulation of renin gene expression across different tissues.

Conclusions:

  • The understanding of renin has undergone a significant conceptual evolution.
  • Intracellular renin and local angiotensin II generation represent a paradigm shift in the field.
  • Further molecular biological research is crucial for fully understanding renin regulation and function.

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