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Sequential Functionalization of meta-C-H and ipso-C-O Bonds of Phenols
Jiancong Xu1, Jingjing Chen1, Feng Gao1
1State Key Laboratory and Institute of Elemento-organic Chemistry, College of Chemistry , Nankai University , Tianjin 300071 , China.
Abstract:
The use of a template as a linchpin motif in directed remote C-H functionalization is a versatile yet relatively underexplored strategy. We have developed a template-directed approach to realizing one-pot sequential palladium-catalyzed meta-selective C-H olefination of phenols, and nickel-catalyzed ipso-C-O activation and arylation. Thus, this bifunctional template converts phenols to synthetically useful 1,3-disubstituted arenes.
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