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Related Experiment Video

Updated: Jan 30, 2026

Activating Autophagy by Aerobic Exercise in Mice

Activating Autophagy by Aerobic Exercise in Mice

Published on: February 3, 2017

Intersections between Regulated Cell Death and Autophagy.

Francesco Napoletano¹, Olga Baron², Peter Vandenabeele³

¹Department of Life Sciences, University of Trieste, Via Weiss 2 - Pal. Q, 34128 Trieste, Italy; CIB National Laboratory, Area Science Park, Padriciano 99, 34149, Trieste, Italy.

Trends in Cell Biology

|January 23, 2019

Summary

This summary is machine-generated.

Regulated cell death (RCD) and autophagy are crucial in multicellular life and disease. This study clarifies RCD identification and explores autophagy

Keywords:

apoptosis autophagy cell death necrosis

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Live Cell Imaging of Early Autophagy Events: Omegasomes and Beyond

Live Cell Imaging of Early Autophagy Events: Omegasomes and Beyond

Published on: July 27, 2013

Area of Science:

Cellular Biology
Molecular Biology
Pathology

Background:

Cell death is fundamental to multicellular organisms.
Regulated cell death (RCD) forms have expanded, impacting diseases like inflammation and neurodegeneration.
Autophagy, a stress response, critically influences cell life and death decisions.

Purpose of the Study:

To introduce criteria and methodologies for accurately identifying different forms of RCD.
To discuss the direct association between the autophagy machinery and specific cell death forms.
To dissect the complex interactions between autophagy and other cell death pathways, including apoptosis and necrosis.

Main Methods:

Review and synthesis of existing literature on RCD identification.
Analysis of experimental data linking autophagy to cell death pathways.
Comparative discussion of interactions between autophagy, apoptosis, and necrosis.

Main Results:

Established criteria for distinguishing various RCD forms.
Demonstrated direct links between autophagy machinery and specific RCD types.
Elucidated complex interplay between autophagy and apoptotic/necrotic cell death.

Conclusions:

The balance between autophagy and other cell death pathways dictates cell fate.
Accurate identification of RCD forms is essential for understanding disease mechanisms.
Autophagy plays a central role in modulating cell survival and death decisions.