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Incidence and Risk Factors for Stroke in Fast-Track Hip and Knee Arthroplasty-A Clinical Registry Study of 24,862
Pelle B Petersen1, Henrik Kehlet2, Christoffer C Jørgensen2
1Section for Surgical Pathophysiology, University of Copenhagen, Copenhagen, Denmark.
Insights
Postoperative stroke risk after fast-track hip or knee replacement is low. Focusing on avoiding perioperative cardiovascular events and managing preoperative anticoagulants or anemia may further reduce stroke incidence.
Area of Science:
- Orthopedic Surgery
- Neurology
- Public Health
Background:
- Postoperative stroke is a severe complication following total hip (THA) and knee arthroplasty (TKA).
- Previous data relied on diagnostic codes, lacking details on perioperative care and fast-track protocols.
- The incidence of stroke after fast-track THA/TKA requires further investigation.
Purpose of the Study:
- To investigate the incidence of stroke after fast-track THA/TKA.
- To identify preoperative and postoperative factors associated with stroke risk.
- To compare stroke incidence with the general population.
Main Methods:
- Observational study of elective fast-track THA/TKA patients.
- Prospective collection of comorbidity data and 90-day follow-up.
- Multivariable logistic regression for risk factor identification and comparison with Danish background population.
Main Results:
- Stroke incidence was 0.11% (≤30 days) and 0.17% (≤90 days) in 24,862 procedures.
- Preoperative risk factors for stroke ≤30 days included age ≥ 85 years and anticoagulant treatment.
- Preoperative anemia was a near-significant risk factor; eight strokes were preceded by early postoperative cardiovascular events.
Conclusions:
- The risk of postoperative stroke in fast-track THA and TKA is low.
- Increased focus on avoiding perioperative cardiovascular events can further reduce stroke risk.
- Patients with preoperative anticoagulants or anemia may benefit from closer monitoring.
Background:
Postoperative stroke is a severe complication with a reported 30-day incidence of 0.4%-0.6% after total hip (THA) and knee arthroplasty (TKA). However, most data are based on diagnostic codes and with limited details on perioperative care, including the use of fast-track protocols. We investigated the incidence of and preoperative and postoperative factors for stroke after fast-track THA/TKA.
Methods:
We used an observational study design of elective fast-track THA/TKA patients with prospective collection of comorbidity and complete 90-day follow-up. Medical records were evaluated for events potentially disposing to stroke. Identification of relevant preoperative risk factors was done by multivariable logistic regression. Incidence of stroke was compared with a Danish background population.
Results:
Of 24,862 procedures with a median length of stay of 2 (interquartile range, 2-3) days, we found 27 (0.11%; 95% confidence interval [CI], 0.08%-0.16%) and 43 strokes (0.17%, 95% CI, 0.13%-0.23%) ≤30 and ≤90 days after surgery, respectively. Preoperative risk factors for stroke ≤30 days were age ≥ 85 years (odds ratio [OR], 4.3; 95% CI, 1.1-16.3) and anticoagulant treatment (OR, 3.1; 95% CI, 1.2-7.9). Preoperative anemia was near significant (OR, 2.1; 95% CI, 0.98-4.6, P = .055). Eight strokes ≤30 days were preceded by a cardiovascular event within the second postoperative day. Incidence of stroke after postoperative day 30 was similar to a Danish background population.
Conclusion:
Risk of postoperative stroke in fast-track THA and TKA was low but may be further reduced with increased focus on avoiding perioperative cardiovascular events and in patients with preoperative anticoagulants or anemia.
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