Incidence and Risk Factors for Stroke in Fast-Track Hip and Knee Arthroplasty-A Clinical Registry Study of 24,862

Pelle B Petersen1, Henrik Kehlet2, Christoffer C Jørgensen2

  • 1Section for Surgical Pathophysiology, University of Copenhagen, Copenhagen, Denmark.

Insights

Postoperative stroke risk after fast-track hip or knee replacement is low. Focusing on avoiding perioperative cardiovascular events and managing preoperative anticoagulants or anemia may further reduce stroke incidence.

Area of Science:

  • Orthopedic Surgery
  • Neurology
  • Public Health

Background:

  • Postoperative stroke is a severe complication following total hip (THA) and knee arthroplasty (TKA).
  • Previous data relied on diagnostic codes, lacking details on perioperative care and fast-track protocols.
  • The incidence of stroke after fast-track THA/TKA requires further investigation.

Purpose of the Study:

  • To investigate the incidence of stroke after fast-track THA/TKA.
  • To identify preoperative and postoperative factors associated with stroke risk.
  • To compare stroke incidence with the general population.

Main Methods:

  • Observational study of elective fast-track THA/TKA patients.
  • Prospective collection of comorbidity data and 90-day follow-up.
  • Multivariable logistic regression for risk factor identification and comparison with Danish background population.

Main Results:

  • Stroke incidence was 0.11% (≤30 days) and 0.17% (≤90 days) in 24,862 procedures.
  • Preoperative risk factors for stroke ≤30 days included age ≥ 85 years and anticoagulant treatment.
  • Preoperative anemia was a near-significant risk factor; eight strokes were preceded by early postoperative cardiovascular events.

Conclusions:

  • The risk of postoperative stroke in fast-track THA and TKA is low.
  • Increased focus on avoiding perioperative cardiovascular events can further reduce stroke risk.
  • Patients with preoperative anticoagulants or anemia may benefit from closer monitoring.
Abstract

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