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Updated: Jan 30, 2026

Hemodynamic Precision in the Neonatal Intensive Care Unit using Targeted Neonatal Echocardiography
Published on: January 27, 2023
Future perspectives on the use of deformation analysis to identify the underlying pathophysiological basis for
Neidin Bussmann1, Afif El-Khuffash2
1Department of Neonatology, The Rotunda Hospital, Dublin, Ireland.
Insights
Assessing cardiovascular health in premature infants is crucial for their outcomes. Echocardiography, including advanced techniques like deformation analysis, helps identify cardiovascular instability in preterm neonates.
Area of Science:
- Neonatal Cardiology
- Pediatric Cardiovascular Research
Background:
- Cardiovascular wellbeing assessment in premature infants is increasingly important.
- Myocardial performance, systemic blood flow, and end-organ perfusion significantly impact preterm infant outcomes, especially during transition.
- Neonatologist Performed Echocardiography (NPE) offers essential techniques for image acquisition, analysis, and clinical application in preterm neonates.
Purpose of the Study:
- To review determinants of cellular metabolism and myocardial performance in preterm infants.
- To discuss the maladaptive cardiovascular state characteristic of preterm infants.
- To highlight the role of non-invasive echocardiography, such as deformation analysis, in understanding cardiovascular instability.
Main Methods:
- Review of current literature on preterm infant cardiovascular physiology.
- Discussion of echocardiographic techniques for assessing myocardial performance and hemodynamics.
- Focus on advanced echocardiographic methods like deformation analysis.
Main Results:
- Identified key factors influencing myocardial performance, including loading conditions, contractility, and morphology.
- Described the unique cardiovascular challenges and maladaptive states in preterm infants.
- Emphasized the utility of echocardiography in pinpointing physiological bases of cardiovascular instability.
Conclusions:
- Non-invasive echocardiography, particularly deformation analysis, is vital for assessing cardiovascular status in preterm infants.
- Understanding cardiovascular physiology through echocardiography aids in improving short- and long-term outcomes for this vulnerable population.
- NPE provides a framework for comprehensive cardiovascular assessment and management in neonatal care.
Abstract:
The assessment of the wellbeing of the cardiovascular status in premature infants has come to the forefront in recent years. There is an increasing realisation that myocardial performance, systemic blood flow and end-organ perfusion (particularly during the transitional period) play an important role in determining short and long-term outcomes in this population. The recent open access series on Neonatologist Performed Echocardiography (NPE) published in this journal outline the necessary techniques for image acquisition and analysis and provide a framework for the potential clinical applications of NPE in neonatal, and specifically preterm care. In this "Future Perspectives" review, we describe the important determinants of adequate cellular metabolism and myocardial performance (e.g. loading conditions, intrinsic contractility and morphological change), we discuss the maladaptive state of the preterm cardiovascular system, and highlight the emerging role that non-invasive echocardiography techniques, such as deformation analysis, serve in identifying the underlying physiological basis for cardiovascular instability.
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