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Epigenetic mechanism and target therapy of UHRF1 protein complex in malignancies

Busheng Xue1, Jiansong Zhao1, Penghui Feng2

  • 1Department of Spine and Joint Surgery, Shengjing Hospital, China Medical University, Shenyang, People's Republic of China, liy15@sj-hospital.org.

Oncotargets and Therapy
|January 23, 2019
PubMed

Insights

Ubiquitin-like with plant homeodomain and really interesting new gene finger domains 1 (UHRF1) is an epigenetic regulator crucial for DNA methylation and histone modifications. Its overexpression is a cancer biomarker, impacting disease progression and response to chemotherapy.

Area of Science:

  • Epigenetics
  • Molecular Biology
  • Cancer Research

Background:

  • Ubiquitin-like with plant homeodomain and really interesting new gene finger domains 1 (UHRF1) is a key epigenetic regulator.
  • UHRF1 maintains DNA methylation and histone modifications by recruiting various proteins.
  • UHRF1 overexpression is implicated in cancer development, progression, and invasion.

Purpose of the Study:

  • To evaluate the role of UHRF1 in the interplay between DNA methylation and histone modifications.
  • To analyze the dynamic structural transformations of UHRF1 in epigenetic regulation.
  • To investigate UHRF1 modifications during the cell cycle and its potential as a chemotherapy target.

Main Methods:

  • Literature review and analysis of UHRF1's molecular functions.
  • Examination of UHRF1's role in epigenetic code replication.
  • Assessment of UHRF1's involvement in cancer biology and therapeutic strategies.

Main Results:

  • UHRF1's recruitment of specific proteins is essential for epigenetic maintenance.
  • Aberrant UHRF1 expression correlates with altered DNA methylation patterns in cancer.
  • UHRF1's structural dynamics are critical for its function in epigenetic regulation.

Conclusions:

  • UHRF1 plays a significant role in maintaining epigenetic homeostasis and is dysregulated in cancer.
  • Understanding UHRF1's structural dynamics and cell cycle modifications can lead to novel therapeutic approaches.
  • Targeting UHRF1 presents a promising strategy for cancer treatment.
Keywords:
ICBP90UHRF1 protein complexepigenetic modification

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