Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

4.9K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
4.9K
Diabetes Mellitus: Overview and Type I Subtype01:22

Diabetes Mellitus: Overview and Type I Subtype

5.3K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
5.3K
Piaget's Stage 2 of Cognitive Development01:14

Piaget's Stage 2 of Cognitive Development

908
The preoperational stage, the second of Jean Piaget's four stages of cognitive development, spans approximately ages 2 to 7 and is characterized by the emergence of symbolic thinking. During this stage, children use language, images, and symbols to represent objects and concepts, enabling them to engage in imaginative and pretend play. This symbolic thinking supports children's ability to perform make-believe actions, such as imagining a broom as a horse or their hand as a phone, blending...
908
Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

3.6K
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
3.6K
Diabetes: Management and Pharmacotherapy01:15

Diabetes: Management and Pharmacotherapy

1.1K
The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
1.1K
Psychoneuroimmunology: Diabetes and Cancer01:19

Psychoneuroimmunology: Diabetes and Cancer

499
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
499

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Proteomic signatures of loss of glycemic control in youth-onset type 2 diabetes in the TODAY study.

The Journal of clinical endocrinology and metabolism·2026
Same author

Structural and functional connectivity in infancy relate to communication skills at age 2 in children born very preterm.

medRxiv : the preprint server for health sciences·2026
Same author

Home Observation for Measurement of the Environment: Collecting Data Virtually.

Clinical pediatrics·2026
Same author

A 2-year randomized trial of pitavastatin calcium vs placebo to treat combined dyslipidemia in adolescents with overweight and obesity.

Journal of clinical lipidology·2026
Same author

Long-Term Effects of Maternal Glycemic Measures in Pregnancy and Offspring Adverse Glycemic Outcomes: Results from the TEAM Study.

American journal of perinatology·2026
Same author

Continuous Glucose Monitoring Identifies Youth with Prediabetes at Risk for Glycemic Progression.

Diabetes technology & therapeutics·2026

Related Experiment Video

Updated: Jan 30, 2026

Author Spotlight: Advancing Diabetes Research with Static Exercise Training in Mice
03:17

Author Spotlight: Advancing Diabetes Research with Static Exercise Training in Mice

Published on: March 29, 2024

1.0K

Youth-Onset Type 2 Diabetes and the Developing Brain.

Jacob M Redel1,2, Lawrence M Dolan3,4, Mark DiFrancesco5,6

  • 1Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA. Jacob.Redel@cchmc.org.

Current Diabetes Reports
|January 23, 2019
PubMed
Summary

Youth-onset type 2 diabetes is linked to cognitive and brain structural changes in adolescents. These findings highlight potential neurodevelopmental impacts during a critical growth period.

Keywords:
BrainCentral nervous systemCognitive functionType 2 diabetesYouth-onset diabetes

More Related Videos

Regulatory T cells: Therapeutic Potential for Treating Transplant Rejection and Type I Diabetes
16:26

Regulatory T cells: Therapeutic Potential for Treating Transplant Rejection and Type I Diabetes

Published on: August 20, 2007

6.2K
Leprdb Mouse Model of Type 2 Diabetes: Pancreatic Islet Isolation and Live-cell 2-Photon Imaging Of Intact Islets
10:09

Leprdb Mouse Model of Type 2 Diabetes: Pancreatic Islet Isolation and Live-cell 2-Photon Imaging Of Intact Islets

Published on: May 11, 2015

10.1K

Related Experiment Videos

Last Updated: Jan 30, 2026

Author Spotlight: Advancing Diabetes Research with Static Exercise Training in Mice
03:17

Author Spotlight: Advancing Diabetes Research with Static Exercise Training in Mice

Published on: March 29, 2024

1.0K
Regulatory T cells: Therapeutic Potential for Treating Transplant Rejection and Type I Diabetes
16:26

Regulatory T cells: Therapeutic Potential for Treating Transplant Rejection and Type I Diabetes

Published on: August 20, 2007

6.2K
Leprdb Mouse Model of Type 2 Diabetes: Pancreatic Islet Isolation and Live-cell 2-Photon Imaging Of Intact Islets
10:09

Leprdb Mouse Model of Type 2 Diabetes: Pancreatic Islet Isolation and Live-cell 2-Photon Imaging Of Intact Islets

Published on: May 11, 2015

10.1K

Area of Science:

  • Neuroscience
  • Endocrinology
  • Pediatrics

Background:

  • Type 2 diabetes is increasingly diagnosed in youth.
  • Adolescent neurodevelopment is ongoing and sensitive to metabolic changes.

Purpose of the Study:

  • To review the literature on the adverse effects of youth-onset type 2 diabetes on the developing brain.
  • To summarize current knowledge regarding cognitive and structural brain alterations.

Main Methods:

  • Literature review of recently published articles.
  • Synthesis of findings from neurocognitive assessments and brain imaging studies.

Main Results:

  • Youth with type 2 diabetes exhibit poorer performance in executive functioning and memory.
  • Brain imaging reveals differences in gray matter, white matter volume, and microstructural integrity.
  • Observed changes are consistent with findings in adult type 2 diabetes literature.

Conclusions:

  • Youth-onset type 2 diabetes is associated with cognitive deficits and brain structural abnormalities.
  • These alterations occur during a critical period of neurodevelopmental maturation.
  • Further research is needed to establish causality and long-term implications.