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Updated: Jan 30, 2026

Author Spotlight: A Unique Mouse Model of Asphyxia-Induced Cardiac Arrest
Published on: April 14, 2023
Experimental models of cardiac physiology and pathology
Jae Gyun Oh1, Changwon Kho1, Roger J Hajjar1
1Icahn School of Medicine at Mount Sinai, New York, USA.
None:
Experimental models of cardiac disease play a key role in understanding the pathophysiology of the disease and developing new therapies. The features of the experimental models should reflect the clinical phenotype, which can have a wide spectrum of underlying mechanisms. We review characteristics of commonly used experimental models of cardiac physiology and pathophysiology in all translational steps including in vitro, small animal, and large animal models. Understanding their characteristics and relevance to clinical disease is the key for successful translation to effective therapies.
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