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Liver Involvement in Congenital Hypopituitarism
Derya Altay1, Erdal Eren2, Tanju Basarır Ozkan3
1Department of Pediatric Gastroenterology, Hepatology and Nutrition, Erciyes University Faculty of Medicine, Kayseri, Turkey. dr.deryaaltay@gmail.com.
Indian Journal of Pediatrics
|January 23, 2019
Summary
Infantile cholestatic jaundice can stem from rare endocrine disorders like hypopituitarism. Prompt hormone replacement therapy resolved liver function abnormalities in studied infants, highlighting the importance of considering hormonal deficiencies.
Area of Science:
- Pediatrics
- Endocrinology
- Hepatology
Background:
- Cholestatic jaundice in infants presents diagnostic challenges.
- Endocrine diseases are an under-recognized cause of cholestasis.
- This study investigates liver dysfunction secondary to hypopituitarism in infants.
Observation:
- Six infants with hypopituitarism-related liver dysfunction were analyzed.
- Patients presented with varying degrees of elevated aminotransferase levels.
- Congenital and acquired hypopituitarism were diagnosed, involving deficiencies in adrenal, thyroid, and growth hormones.
Findings:
- Liver function abnormalities in infants were linked to hormonal deficiencies.
- Hormone replacement therapy led to the resolution of liver dysfunction.
- Resolution occurred within 10 days to 2 months post-treatment.
Implications:
- Pediatricians should consider hormonal deficiencies in infant cholestasis differential diagnoses.
- Early diagnosis and hormone replacement are crucial for managing liver dysfunction in hypopituitarism.
- Recognizing endocrine causes of neonatal cholestasis improves patient outcomes.
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