Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Compass01:23

Compass

6.8K
The compass is a fundamental instrument that operates by aligning its magnetic needle with Earth's magnetic field. This alignment facilitates navigation and orientation, offering a means to determine direction relative to magnetic north. However, the magnetic needle points to magnetic north, which differs slightly from true geographic north due to magnetic declination, which is the angular deviation between these two points. Declination varies based on geographic location and shifts over time...
6.8K
Design Example: Marking Boundaries of a Site Using a Compass01:12

Design Example: Marking Boundaries of a Site Using a Compass

291
Marking site boundaries using a compass is a precise surveying technique that ensures the accuracy of boundary delineation. The process begins by using provided site details, including the bearings and lengths of each boundary line. The initial step involves calculating latitudes and departures for all sides of the site. This computation verifies that the traverse is free of errors, ensuring a closed and accurate boundary.The process starts at a known point, such as Point A, which is often...
291
Clinical Trials: Overview01:11

Clinical Trials: Overview

4.9K
Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
4.9K
Trial and Error and Algorithm01:12

Trial and Error and Algorithm

407
A problem-solving strategy is a plan of action used to find a solution. Different strategies have distinct action plans. Trial and error involves trying different solutions until one works. For instance, to fix a broken printer, you might check ink levels, ensure the paper tray isn't jammed, and verify the printer's connection to your laptop. This method can be time-consuming but is commonly used. Thomas Edison, for example, used trial and error to find a suitable filament for the light...
407
Clinical Trials01:16

Clinical Trials

10.4K
Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
10.4K
Predicting Reaction Outcomes02:24

Predicting Reaction Outcomes

10.8K
Kinetics describes the rate and path by which a reaction occurs. In contrast, thermodynamics deals with state functions and describes the properties, behavior, and components of a system. It is not concerned with the path taken by the process and cannot address the rate at which a reaction occurs. Although it does provide information about what can happen during a reaction process, it does not describe the detailed steps of what appears on an atomic or a molecular level. On the other hand,...
10.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The role of Lipoprotein(a) and oxidized phospholipids in modifying the effects of aspirin on major cardiovascular events and bleeding in the ASPirin in Reducing Events in the Elderly (ASPREE) randomized clinical trial: Statistical analysis plan.

medRxiv : the preprint server for health sciences·2026
Same author

Cognitive Decline Preceding Incident Cardiovascular Events in Older Adults.

JAMA network open·2026
Same author

Cardiac resynchronization therapy with or without atrioventricular node ablation in atrial fibrillation: the CAAN-AF trial.

European heart journal·2026
Same author

The effects of daily low-dose aspirin on white matter hyperintensity lesions and retinal vascular calibre in healthy older adults: the ENVIS-ion exploratory neuroimaging substudy of the ASPREE randomised clinical trial.

The lancet. Healthy longevity·2026
Same author

Transitions From Frailty States to Cardiovascular Events: An 11-Year Prospective Study of Community-Dwelling Older People.

The Canadian journal of cardiology·2025
Same author

Clinical characteristics, management and outcomes of enterococcal infective endocarditis: an ancillary study from the ESC-EORP EURO-ENDO registry.

European heart journal. Quality of care & clinical outcomes·2025

Related Experiment Video

Updated: Jan 30, 2026

Randomized, Triple-Blind, and Parallel-Controlled Trial of Transcranial Direct Current Stimulation for Cognitive Rehabilitation after Stroke
08:53

Randomized, Triple-Blind, and Parallel-Controlled Trial of Transcranial Direct Current Stimulation for Cognitive Rehabilitation after Stroke

Published on: June 6, 2025

1.8K

Stroke Outcomes in the COMPASS Trial.

Mukul Sharma1, Robert G Hart1, Stuart J Connolly1

  • 1McMaster University/Population Health Research Institute, Hamilton, Canada (M.S., R.G.H., S.J.C., J.B., O.S., K.K.H.N., L.C., S.Y., J.W.E.).

Circulation
|January 23, 2019
PubMed
Summary

The combination of rivaroxaban and aspirin significantly reduced strokes in patients with atherosclerosis compared to aspirin alone. This combination therapy offers a new antithrombotic strategy for stroke prevention.

Keywords:
aspirinatherosclerosisprevention and controlrandomized controlled trialrivaroxabanstroke

More Related Videos

Author Spotlight: Innovative Techniques and Future Directions in Stroke Research
04:46

Author Spotlight: Innovative Techniques and Future Directions in Stroke Research

Published on: May 5, 2023

5.5K
Modeling Stroke in Mice: Permanent Coagulation of the Distal Middle Cerebral Artery
08:14

Modeling Stroke in Mice: Permanent Coagulation of the Distal Middle Cerebral Artery

Published on: July 31, 2014

38.5K

Related Experiment Videos

Last Updated: Jan 30, 2026

Randomized, Triple-Blind, and Parallel-Controlled Trial of Transcranial Direct Current Stimulation for Cognitive Rehabilitation after Stroke
08:53

Randomized, Triple-Blind, and Parallel-Controlled Trial of Transcranial Direct Current Stimulation for Cognitive Rehabilitation after Stroke

Published on: June 6, 2025

1.8K
Author Spotlight: Innovative Techniques and Future Directions in Stroke Research
04:46

Author Spotlight: Innovative Techniques and Future Directions in Stroke Research

Published on: May 5, 2023

5.5K
Modeling Stroke in Mice: Permanent Coagulation of the Distal Middle Cerebral Artery
08:14

Modeling Stroke in Mice: Permanent Coagulation of the Distal Middle Cerebral Artery

Published on: July 31, 2014

38.5K

Area of Science:

  • Cardiovascular Medicine
  • Pharmacology
  • Neurology

Background:

  • The COMPASS trial investigated antithrombotic strategies for patients with stable coronary artery or peripheral artery disease.
  • Stroke reduction was a key outcome measure in the trial.
  • Previous analyses showed a significant benefit of rivaroxaban plus aspirin over aspirin alone.

Purpose of the Study:

  • To present detailed analyses of stroke by type, predictors, and antithrombotic effects in key subgroups from the COMPASS trial.
  • To evaluate the efficacy of rivaroxaban plus aspirin versus aspirin alone in preventing different types of strokes.
  • To identify independent predictors of stroke in patients with established atherosclerotic disease.

Main Methods:

  • A randomized trial involving patients with stable coronary artery or peripheral artery disease.
  • Three treatment arms: aspirin 100 mg once daily, rivaroxaban 5 mg twice daily, and rivaroxaban 2.5 mg twice daily plus aspirin.
  • Exclusion criteria included need for anticoagulation, recent stroke, lacunar stroke history, or intracerebral hemorrhage.

Main Results:

  • The combination of rivaroxaban plus aspirin significantly reduced overall stroke occurrence compared to aspirin alone (HR, 0.58; P<0.0001).
  • Ischemic/uncertain strokes were reduced by nearly half with the combination therapy (HR, 0.51; P<0.0001).
  • Fatal and disabling strokes were also decreased by the combination (HR, 0.58; P=0.01).
  • Prior stroke was the strongest independent predictor of incident stroke (HR, 3.63; P<0.0001).
  • The benefit of the combination was consistent across high-stroke-risk subgroups, including those with prior stroke.

Conclusions:

  • Low-dose rivaroxaban plus aspirin represents a significant advancement in antithrombotic therapy.
  • This combination is an effective option for both primary and secondary stroke prevention in patients with clinical atherosclerosis.
  • The findings support the use of rivaroxaban plus aspirin in specific patient populations at high risk for stroke.