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Updated: Jan 30, 2026
10:25
Brain Infarct Segmentation and Registration on MRI or CT for Lesion-symptom Mapping
Published on: September 25, 2019
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Demyelinating lesions behaving like aggressive tumours on advanced MRI techniques
Brainner Campos Barbosa1, Edson Marchiori2, Caio Leal Leidersnaider3
11 Department of Radiology, Pontifical Catholic University of Goias School of Medicine, Goiania, Brazil.
The Neuroradiology Journal
|January 23, 2019
Summary
Tumefactive demyelinating lesions can mimic brain tumors on MRI. Atypical high perfusion/permeability findings in these lesions should not rule out demyelination, preventing misdiagnosis.
Area of Science:
- Neurology
- Radiology
- Neuroimaging
Background:
- Tumefactive demyelinating lesions (TDLs) are rare inflammatory brain disorders.
- TDLs can be misdiagnosed as primary brain tumors like glioma or lymphoma.
- Accurate diagnosis is crucial to avoid unnecessary surgical intervention.
Observation:
- This study reports three cases of TDLs with atypical imaging features.
- Lesions presented with high perfusion and, in two cases, high permeability on MRI.
- These findings are typically associated with high-grade neoplastic lesions.
Findings:
- Conventional MRI may show features suggestive of demyelination in TDLs.
- Atypical findings of increased perfusion and permeability can occur in TDLs.
- These atypical features are more commonly observed in high-grade gliomas.
Implications:
- Radiologists should consider TDLs even with atypical high perfusion/permeability findings.
- Recognizing these imaging patterns can expedite appropriate management for TDLs.
- Distinguishing TDLs from high-grade gliomas is essential for patient treatment.
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