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In Vitro Endothelialization of Surface-Integrated Nanofiber Networks for Stretchable Blood Interfaces.

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A novel nanofiber surface modification enhances elastic silicone for ventricular assist devices (VADs), reducing blood clot risk and promoting endothelial cell growth for improved long-term function.

Keywords:
electrospun composite materialsendothelializationfluorinated surface functionalizationpulsatile flow bioreactorthrombogenicity

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Area of Science:

  • Biomaterials Science
  • Cardiovascular Engineering
  • Medical Device Technology

Background:

  • Thromboembolic events on artificial surfaces remain a significant challenge for ventricular assist devices (VADs).
  • Current VAD materials limit mid- to long-term functionality due to blood-material interactions.
  • Developing improved blood-contacting surfaces is crucial for next-generation VADs.

Purpose of the Study:

  • To create a biomimetic blood-material interface using a nanofiber approach.
  • To enhance the endothelialization capability of elastic silicone surfaces for VAD applications.
  • To improve the antithrombotic properties of VAD materials under hemodynamic loads.

Main Methods:

  • Fabrication of a blend fiber membrane from elastic polyurethane and poly(vinylidene fluoride-co-hexafluoropropylene).
  • Partial embedding of the blend membrane into silicone films to create a composite material.
  • Evaluation of endothelial cell formation on the modified surface in a pulsatile flow bioreactor.

Main Results:

  • The composite material exhibited enhanced antithrombotic properties compared to bare silicone.
  • The nanofiber surface modification promoted the formation of a stable endothelial cell monolayer.
  • The modified silicone surfaces demonstrated resistance to irreversible deformation under load.

Conclusions:

  • Nanofiber surface modification is a promising strategy for developing advanced elastic composite materials for blood-contacting applications.
  • This approach can improve the hemocompatibility and functionality of ventricular assist devices.
  • The biomimetic interface design addresses key challenges in VAD therapy.