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Updated: Jan 30, 2026
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Capsular Serotyping of Streptococcus pneumoniae Using the Quellung Reaction
Published on: February 24, 2014
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Invasive pneumococcal disease in relation to vaccine type serotypes
Paeton L Wantuch1, Fikri Y Avci1
1a Department of Biochemistry and Molecular Biology, Center for Molecular Medicine and Complex Carbohydrate Research Center , University of Georgia , Athens , GA , USA.
Human Vaccines & Immunotherapeutics
|January 23, 2019
Summary
Despite widespread vaccination, Streptococcus pneumoniae infections remain a global health burden. Current vaccines are surprisingly ineffective against prevalent serotypes, necessitating novel strategies for invasive pneumococcal disease (IPD) control.
Area of Science:
- Microbiology
- Immunology
- Vaccinology
Background:
- Four Streptococcus pneumoniae vaccines have been developed since 1983.
- Despite vaccination, S. pneumoniae causes significant global morbidity and mortality.
Discussion:
- Invasive pneumococcal disease (IPD) is still caused by serotypes targeted by current vaccines, like 3 and 19A.
- Non-vaccine serotypes, such as 35B, are emerging and increasing.
Key Insights:
- Current vaccines exhibit limited efficacy against dominant S. pneumoniae serotypes.
- A rise in non-vaccine serotype IPD indicates evolving bacterial resistance to vaccination.
Outlook:
- Further research is crucial for designing improved conjugate vaccines.
- Novel strategies are required to effectively combat invasive pneumococcal disease.
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