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Epithelial-mesenchymal transition as a target for botanicals in cancer metastasis

Bahare Salehi1, Elena Maria Varoni2, Mehdi Sharifi-Rad3

  • 1Medical Ethics and Law Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Student Research Committee, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Phytomedicine : International Journal of Phytotherapy and Phytopharmacology
|January 23, 2019
PubMed
Abstract

Insights

Plants offer promising anticancer drugs by targeting epithelial-mesenchymal transition (EMT). Phenylpropanoids show potential, but clinical evidence is needed.

Area of Science:

  • Phytochemistry
  • Oncology
  • Drug Discovery

Background:

  • The plant kingdom is a rich source of phytotherapeutics for anticancer drug discovery.
  • Epithelial-mesenchymal transition (EMT) is a key process in cancer progression and metastasis.
  • Targeting EMT offers a novel therapeutic strategy in cancer treatment.

Purpose of the Study:

  • To review bioactive phytochemicals with anti-epithelial-mesenchymal transition (EMT) activity.
  • To provide an updated overview of natural compounds targeting EMT in cancer therapy.

Main Methods:

  • Narrative review of scientific literature.
  • Focus on preclinical and clinical studies of phytochemicals and their anti-EMT effects.

Main Results:

  • Phenylpropanoids were the most studied phytochemical class with anti-EMT activity.
  • Several plant-derived compounds demonstrated significant preclinical anti-EMT effects.

Conclusions:

  • Phenylpropanoids show promising anticancer potential by targeting EMT.
  • Further clinical research is required to establish the efficacy of these phytotherapeutics in cancer patients.
Keywords:
AlkaloidsAnticancer phytotherapeuticsBioactive phytochemicalsChemopreventionIsoprenoidsPhenylpropanoids

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