Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Riboswitches

Riboswitches

Riboswitches are non-coding mRNA domains that regulate the transcription and translation of downstream genes without the help of proteins. Riboswitches bind directly to a metabolite and can form unique stem-loop or hairpin structures in response to the amount of the metabolite present. They have two distinct regions – a metabolite-binding aptamer and an expression platform.
The aptamer has high specificity for a particular metabolite which allows riboswitches to specifically regulate...

Eukaryotic RNA Polymerases

Eukaryotic RNA Polymerases

RNA Polymerase (RNAP) is conserved in all animals, with bacterial, archaeal, and eukaryotic RNAPs sharing significant sequence, structural, and functional similarities. Among the three eukaryotic RNAPs, RNA Polymerase II is most similar to bacterial RNAP in terms of both structural organization and folding topologies of the enzyme subunits. However, these similarities are not reflected in their mechanism of action.
All three eukaryotic RNAPs require specific transcription factors, of which the...

Nonsense-mediated mRNA Decay

Nonsense-mediated mRNA Decay

The Upf proteins that carry out nonsense-mediated decay (NMD) are found in all eukaryotic organisms, including humans. Each protein has an individual role, but they need to work in collaboration. Upf1 is an ATP-dependent RNA helicase that unwinds the RNA helix. Because Upf1 can unwind any RNA, Upf2 and Upf3 are required to help Upf1 discriminate between nonsense and normal mRNAs.
Usually, Upf3 binds to an Exon Junction Complex (EJC) at mRNA splice sites. If a ribosome fully translates the mRNA,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

The FLASH Effect in 3D and 2D Models: Preserving Tumor Control while Reducing Apoptosis in Normal Cells.

Radiation research·2026

Same author

Molecular plating for targetry: proof of concept using <sup>nat</sup>Gd(p,x)<sup>155</sup>Tb cross section measurements.

Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine·2026

Same author

Experimental and simulated <math><semantics><mrow><msub><mi>H</mi> <mn>2</mn></msub> <msub><mi>O</mi> <mn>2</mn></msub></mrow> <annotation>${{{\mathrm{H}}}_2}{{{\mathrm{O}}}_2}$</annotation></semantics></math> in pure water under conventional and ultra-high dose rates for single pulse proton irradiation.

Medical physics·2026

Same author

<sup>211</sup>At targeted alpha therapy in Europe: overcoming clinical, regulatory, and infrastructure challenges.

European journal of nuclear medicine and molecular imaging·2026

Same author

["Tumor Targeting, Imaging, RadiotherapieS" 17th edition of the workshop organized by the Cancéropôle Grand-Ouest, October 9-12, 2024, Erquy, France].

Bulletin du cancer·2026

Same author

The FLASH Effect in 3D and 2D Models: Preserving Tumor Control while Reducing Apoptosis in Normal Cells.

Radiation research·2026

Search research articles

Related Experiment Video

Updated: Jan 30, 2026

Use of a Linear Accelerator for Conducting In Vitro Radiobiology Experiments

Use of a Linear Accelerator for Conducting In Vitro Radiobiology Experiments

Published on: May 26, 2019

THE RADIOBIOLOGICAL PLATFORM AT ARRONAX.

Charbel Koumeir¹, Viviana De Nadal², Roberto Cherubini²

¹GIP ARRONAX, Saint-Herblain, France.

Radiation Protection Dosimetry

|January 23, 2019

Summary

The ARRONAX cyclotron facility is equipped for radiobiological studies, successfully demonstrating cell survival assessments using 68 MeV protons. This confirms its high potential for radiation-matter interaction research.

More Related Videos

Platform Incubator with Movable XY Stage: A New Platform for Implementing In-Cell Fast Photochemical Oxidation of Proteins

Platform Incubator with Movable XY Stage: A New Platform for Implementing In-Cell Fast Photochemical Oxidation of Proteins

Published on: May 17, 2021

A Robotic Platform to Study the Foreflipper of the California Sea Lion

A Robotic Platform to Study the Foreflipper of the California Sea Lion

Published on: January 10, 2017

Related Experiment Videos

Last Updated: Jan 30, 2026

Use of a Linear Accelerator for Conducting In Vitro Radiobiology Experiments

Use of a Linear Accelerator for Conducting In Vitro Radiobiology Experiments

Published on: May 26, 2019

Platform Incubator with Movable XY Stage: A New Platform for Implementing In-Cell Fast Photochemical Oxidation of Proteins

Platform Incubator with Movable XY Stage: A New Platform for Implementing In-Cell Fast Photochemical Oxidation of Proteins

Published on: May 17, 2021

A Robotic Platform to Study the Foreflipper of the California Sea Lion

A Robotic Platform to Study the Foreflipper of the California Sea Lion

Published on: January 10, 2017

Area of Science:

Nuclear Physics
Radiobiology
Radiation Oncology

Background:

The Advanced Research and Radionuclide Production ARRONAX cyclotron facility offers versatile particle beams.
One experimental hall is optimized for studying radiation interactions with biological matter.

Purpose of the Study:

To establish and characterize a horizontal beamline for cell irradiation.
To perform radiobiological characterization using proton beams.

Main Methods:

Setup and characterization of a horizontal beamline at the ARRONAX cyclotron.
Irradiation of V79 cells with 68 MeV protons.
Assessment of V79 cell survival post-irradiation.

Main Results:

Successful setup and characterization of the cell irradiation beamline.
Quantification of V79 cell survival following 68 MeV proton irradiation.
Demonstration of the facility's capability for radiobiological research.

Conclusions:

The ARRONAX facility is well-suited for radiobiological studies.
The characterized beamline and experimental procedures confirm the facility's high potential for radiation-matter interaction research.