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Published on: July 13, 2019
Candidaemia in an Irish intensive care unit setting between 2004 and 2018 reflects increased incidence of Candida
P Ryan1, C Motherway2, J Powell2
1Centre for Interventions in Infection, Inflammation & Immunity and Graduate Entry Medical School, University of Limerick, Limerick, Ireland.
Abstract:
The cumulative incidence of candidaemia in an Irish intensive care unit (ICU) setting between January 2004 and August 2018 was 17/1000 ICU admissions. Candida albicans was responsible for 55% (N=41) of cases. C. glabrata (N=21, 28%) was the next most prevalent species, and has been identified most frequently since 2012. C. glabrata was associated with a higher mortality rate (57%) than C. albicans (29%). All isolates were susceptible to caspofungin (0.05 μg/mL). Notably, 37% of C. glabrata isolates were resistant to fluconazole, with 13% resistant to amphotericin B, highlighting the need for prudent antifungal stewardship to impede development of multi-drug-resistant C. glabrata in the ICU setting.
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