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Structural covariability hubs in old age.

Lars Forsberg1, Sigurdur Sigurdsson2, Lenore J Launer3

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Summary
This summary is machine-generated.

This study mapped brain structural organization in 960 healthy adults using advanced computing. Key brain hubs, crucial for behavior, were identified in subcortical regions, showing no age or sex differences.

Keywords:
ExaptationGrey matterStructural covarianceVoxel-based morphometry

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Area of Science:

  • Neuroimaging
  • Structural Brain Organization
  • Computational Neuroscience

Background:

  • Inter-individual differences in grey matter are coordinated across brain voxels.
  • Previous studies used limited seed regions to map these covariances.
  • Voxel-based morphometry is a key technique for analyzing structural differences.

Purpose of the Study:

  • To compute the aggregated map of total structural topographical organization in the brain at the voxel level.
  • To identify brain hubs based on significant correlations between grey matter voxels.
  • To investigate the influence of age and sex on these structural relationships in healthy adults.

Main Methods:

  • Utilized Graphics Processing Unit (GPU)-based accelerated computing for efficient calculation.
  • Analyzed a large sample of 960 healthy individuals aged 68-83 years.
  • Calculated voxel-wise correlations to create an aggregated topographical organization map.

Main Results:

  • Identified brain hubs, defined as voxels significantly correlating with numerous other grey matter voxels.
  • A majority of these hubs were located in evolutionarily preserved subcortical regions: basal ganglia, thalamus, brainstem, and cerebellum.
  • No significant differences in covariability were observed with increasing age or between sexes in these identified hubs.

Conclusions:

  • Structural topographical organization in the brain can be mapped comprehensively at the voxel level.
  • Subcortical regions play a central role as structural hubs, integrating information across the neocortex.
  • The identified structural hub organization is robust across age and sex in healthy older adults.