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Updated: Jan 30, 2026

Generation of Cancer Cell Clones to Visualize Telomeric Repeat-containing RNA TERRA Expressed from a Single Telomere in Living Cells
Published on: January 17, 2019
Telomere Biology and Human Phenotype
Kara J Turner1, Vimal Vasu2,3, Darren K Griffin4
1University of Kent, School of Biosciences, Giles Lane, Canterbury, Kent, CT2-7NJ, UK. k.j.turner-24@kent.ac.uk.
Abstract:
Telomeres are nucleoprotein structures that cap the end of each chromosome arm and function to maintain genome stability. The length of telomeres is known to shorten with each cell division and it is well-established that telomere attrition is related to replicative capacity in vitro. Moreover, telomere loss is also correlated with the process of aging in vivo. In this review, we discuss the mechanisms that lead to telomere shortening and summarise telomere homeostasis in humans throughout a lifetime. In addition, we discuss the available evidence that shows that telomere shortening is related to human aging and the onset of age-related disease.
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