[Anti-angina effect of foridon in patients with stable exertion-induced stenocardia]

Twenty-three patients with coronary heart disease and stable angina of effort who took a single dose (30 mg) of ryodipine and nifedipine underwent exercise tests on a bicycle ergometer. Ten patients received ryodipine in two doses and placebo by a single-blind protocol. The single dise of ryodipine increased exercise time by 36% and intensity by 40%. Nifedipine produced the same action. When given in a dose of 150 mg/day for a short period of time, ryodipine reduced the frequency of anginal attacks by 39% and the number of nitroglycerin tablets used by 30%. The duration of physical exercise and its performance were increased by 53% and 63%, respectively. The effect was identical at 250 mg per day. The results proved ryodipine to be an effective antianginal agent.