[Numerical simulation study of type B aortic dissection using patient-specific reverse engineering and...

Area of Science:

• Cardiovascular Engineering
• Medical Imaging
• Computational Fluid Dynamics

Background:

• Type B aortic dissection (TBAD) presents complex hemodynamics influencing disease progression.
• Understanding aortic remodeling in TBAD is critical for effective treatment strategies.
• Patient-specific modeling offers a powerful tool for dissecting TBAD biomechanics.

Purpose of the Study:

• To develop a patient-specific computational fluid model (CFM) for Type B Aortic Dissection (TBAD).
• To utilize fluid-structure interaction (FSI) for analyzing aortic remodeling in TBAD.
• To evaluate the CFM's application in predicting TBAD progression and therapeutic outcomes.

Main Methods:

• Acquired patient-specific computed tomographic angiograph data for 3D model reconstruction.
• Employed Mimics and Geomagic for reverse engineering and model smoothing.
• Performed computational fluid dynamics (CFD) simulations with two-way fluid-structure interaction (FSI) in ANSYS.

Main Results:

• Successfully constructed a patient-specific CFM for TBAD using FSI.
• Identified high wall stress at the false lumen, converging at tear entry points.
• Observed altered blood flow patterns post-intervention, promoting thrombus remodeling and indicating risks for distal aneurysm formation.

Conclusions:

• The developed CFM accurately represents blood dynamics and wall pressure in TBAD.
• Patient-specific CFM with FSI is valuable for understanding TBAD pathophysiology.
• This approach aids in predicting aortic remodeling and informing treatment strategies for TBAD.