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Correlation between RBC changes and coagulation parameters in high altitude population.

Rong Zhang1, Xiaochuan Yu2, Yuanzhen Shen2

  • 1a Institute of Blood Transfusion, Chinese Academy of Medical Sciences and Peking Union Medical College , Chengdu , People's Republic of China.

Hematology (Amsterdam, Netherlands)
|January 24, 2019
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Summary

Red blood cell (RBC) indexes like hemoglobin (HGB) and hematocrit (HCT) showed limited correlation with basic coagulation parameters in high-altitude populations. These RBC indexes may independently predict thrombotic disease risk.

Keywords:
High altitudecoagulation parametershematocrithemoglobinred blood cells

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Area of Science:

  • Hematology
  • High-altitude physiology
  • Thrombotic disease research

Background:

  • High altitude is associated with increased risk of thrombotic diseases.
  • Red blood cell (RBC) indexes, including hemoglobin (HGB) and hematocrit (HCT), are altered at high altitudes.
  • The relationship between RBC indexes and coagulation parameters in high-altitude populations requires further investigation.

Purpose of the Study:

  • To investigate the correlations between RBC indexes (HGB, HCT) and basic coagulation parameters (PT, APTT, TT, Fbg).
  • To provide data for understanding high altitude-induced thrombotic disease.

Main Methods:

  • 433 volunteers at high altitude were grouped by HGB and HCT levels.
  • Prothrombin time (PT), activated partial thromboplastin time (APTT), thrombin time (TT), and fibrinogen (Fbg) were measured.
  • HGB, HCT, and platelet (PLT) counts were assessed using an automated hematology analyzer.

Main Results:

  • Higher HGB or HCT groups showed significantly higher APTT and PT.
  • Platelet (PLT) count was significantly lower in high HGB/HCT groups.
  • APTT and PT negatively correlated with HGB, but positively with HCT; PLT, TT, and Fbg showed no significant correlation with HGB or HCT.

Conclusions:

  • HGB and HCT may not strongly correlate with basic coagulation parameters in high-altitude populations.
  • The predictive value of HGB and HCT for high altitude-induced thrombotic disease might be relatively independent.
  • Further studies are needed to confirm these findings and their clinical implications.