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Signal Acquisition, Score Interpretation, and Economics of a Non-Invasive Point-of-Care Test for Coronary Artery Disease
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The triglyceride paradox in the mortality of coronary artery disease

Tian-Li Xia1, Yi-Ming Li2, Fang-Yang Huang1

  • 1Department of Cardiology, West China Hospital, Sichuan University, 37 Guoxue Street, Chengdu, 610041, People's Republic of China.

Lipids in Health and Disease
|January 24, 2019
PubMed

Insights

Higher triglyceride (TG) levels in coronary artery disease (CAD) patients were associated with a lower risk of long-term mortality. This study suggests a "TG paradox" may be present in CAD secondary prevention.

Area of Science:

  • Cardiology
  • Clinical Research
  • Public Health

Background:

  • The role of triglyceride (TG) in secondary prevention for coronary artery disease (CAD) patients remains debated.
  • This study investigated the association between admission TG levels and long-term mortality risk in CAD patients.

Purpose of the Study:

  • To assess the relationship between admission triglyceride levels and mortality in patients with coronary artery disease.
  • To determine if higher TG levels are associated with increased or decreased long-term mortality in CAD patients.

Main Methods:

  • Retrospective analysis of 3061 CAD patients confirmed by coronary angiography.
  • Patients were categorized into three groups based on admission serum TG tertiles.
  • Primary endpoint: all-cause mortality; Secondary endpoint: cardiovascular mortality.

Main Results:

  • A mean follow-up of 26.9 months revealed 258 deaths and 146 cardiovascular deaths.
  • Cumulative survival analysis showed a decreased risk of all-cause death with increasing TG levels (p=0.001).
  • Cox regression confirmed an independent inverse correlation between TG levels and both all-cause (HR 0.71) and cardiovascular mortality (HR 0.67).

Conclusions:

  • An inverse association exists between triglyceride levels and mortality risk in CAD patients.
  • The findings suggest a potential "TG paradox" in the context of secondary prevention for CAD.
  • This challenges traditional views on TG as solely a risk factor in CAD.
Abstract

Keywords:
HypertriglyceridemiaParadoxPrognosis

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