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5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat
Published on: July 3, 2013
Fueling Ketone Metabolism Quenches Salt-Induced Hypertension
David E Place1, Thirumala-Devi Kanneganti1
1Department of Immunology, St Jude Children's Research Hospital, Memphis, TN 38105, USA.
Abstract:
Understanding the molecular mechanisms by which diet and exercise regulate disease has the potential to help identify new treatments. In their recent study, Chakraborty et al. (Cell Reports 2018;25:677-689) discovered that supplementation with a metabolic precursor produced β-hydroxybutyrate (BHB), counteracting the pathological effects of high-salt diet-induced hypertension, suggesting a new treatment modality.
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