Related Experiment Video

Updated: Aug 17, 2026

Rapid In Vivo Assessment of Adjuvant's Cytotoxic T Lymphocytes Generation Capabilities for Vaccine Development
09:03

Rapid In Vivo Assessment of Adjuvant's Cytotoxic T Lymphocytes Generation Capabilities for Vaccine Development

Published on: June 19, 2018

[Immunotoxicology]

J Hanke, J A Indulski

    Medycyna Pracy
    |January 1, 1988
    PubMed

    The aim of the present paper is to inform Polish occupational physicians about a new medical discipline called immunotoxicology which developed during last decades. The importance of immunotoxicology resides in the fact that examinations performed on its basis make it possible to understand some toxic mechanisms which could not have been explained so far studying biochemical disorders. Immunotoxicology is regarded as an extension of toxicology. According to the principles of immunology, organism's reactions to xenobiotics action depends on the mechanisms regulating immunological system, i.e. on its activity or suppression. Considering the present scientific achievements, it can be said that both these states are related to disregulation of homeostatic mechanisms. Owing to the informative nature of this paper, many examples of immunological reactions were adopted from the relatively rich world literature. Readers who are interested in more comprehensive information may refer to source literature.

    More Related Videos

    Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo12:42

    Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo

    Published on: January 7, 2019

    Tailoring In Vivo Cytotoxicity Assays to Study Immunodominance in Tumor-specific CD8+ T Cell Responses10:13

    Tailoring In Vivo Cytotoxicity Assays to Study Immunodominance in Tumor-specific CD8+ T Cell Responses

    Published on: May 6, 2019

    Related Concept Videos

    Cell-mediated Immune Responses01:40

    Cell-mediated Immune Responses

    Overview
    Cytotoxic T Cells-mediated Immune Response01:27

    Cytotoxic T Cells-mediated Immune Response

    Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
    Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
    Toxicity Testing in Animals01:23

    Toxicity Testing in Animals

    Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...