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Updated: Jan 30, 2026

Isolation of Cancer Stem Cells From Human Prostate Cancer Samples
Published on: March 14, 2014
Depression Stresses the Immune Response and Promotes Prostate Cancer Growth
Hemn Mohammadpour1, Mark J Bucsek2, Bonnie L Hylander2
1Department of Immunology, Roswell Park Comprehensive Cancer Center, Buffalo, New York. hemn.mohammadpour@RoswellPark.org.
Abstract:
Depression induces secretion of neuropeptide Y from prostate cancer cells, which, in turn, recruits myeloid-derived suppressor cells (MDSC) to the tumor; tumor cells and MDSCs secrete IL6, which activates STAT3 within cancer cells. Prostate cancer samples from depressed patients reveal a similar phenotype, suggesting new treatment strategies based upon blockade of β2-adrenergic receptors and/or neuropeptide Y.See related article by Cheng et al., p. 2621.
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