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Updated: Jan 30, 2026
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A Double Humanized BLT-mice Model Featuring a Stable Human-Like Gut Microbiome and Human Immune System
Published on: August 30, 2019
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Role of the microbiome in human development.
Maria Gloria Dominguez-Bello1, Filipa Godoy-Vitorino2, Rob Knight3
1Department of Biochemistry and Microbiology, Rutgers, the State University of New Jersey, New Brunswick, New Jersey, USA.
Gut
|January 24, 2019
Summary
The human microbiome, a collection of microbes, coevolved with hosts, influencing health from gestation through development. Maintaining a healthy microbiome is crucial for host well-being and disease resistance.
Area of Science:
- Microbiology
- Human Biology
- Evolutionary Biology
Background:
- The host-microbiome supraorganism highlights the coevolutionary relationship between humans and their resident microbes.
- Microbiota plays a critical role in host health, influencing development, immunity, and pathogen resistance from gestation onwards.
Purpose of the Study:
- To review the multifaceted role of the human microbiome in host development, encompassing evolutionary aspects.
- To examine maternal-fetal microbiome interactions, nutritional contributions, and growth modulation.
- To discuss the characteristics of a healthy microbiota, the impact of modern practices, and disease associations.
Main Methods:
- Literature review synthesizing current research on host-microbiome interactions.
- Analysis of evolutionary perspectives on microbiome development and function.
- Examination of epidemiological data linking microbiota perturbations to diseases.
Main Results:
- The human microbiome is integral to physiological development, immunity, and nutrition, starting in utero.
- Antimicrobial practices can disrupt the delicate balance of the microbiota, potentially leading to health issues.
- Microbiota perturbations are increasingly associated with the rise of diseases in urban populations.
Conclusions:
- The human microbiome is a vital component of host health, shaped by coevolution and early-life exposures.
- Restoring and maintaining a healthy microbiome is essential for preventing and managing diseases, particularly in modern societies.
- Understanding the microbiome's role offers potential therapeutic avenues for various health conditions.
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