Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The functional conversion hypothesis: a contributor to exercise-induced asthma?

C S Venugopalan1, H J Jenkins, J M Drazen

  • 1Department of Veterinary Physiology, Pharmacology and Toxicology, School of Veterinary Medicine, Louisiana State University, Baton Rouge 70803.

Medical Hypotheses
|December 1, 1988
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Characteristics and Effectiveness of Interventions That Target the Reporting, Communication, or Clinical Interpretation of Lumbar Imaging Findings: A Systematic Review.

AJNR. American journal of neuroradiology·2022
Same author

Understanding patient beliefs regarding the use of imaging in the management of low back pain.

European journal of pain (London, England)·2015
Same author

Global strategy for asthma management and prevention: GINA executive summary.

The European respiratory journal·2008
Same author

[Registration of clinical trials: a statement from the International Committee of Medical Journal Editors].

Nederlands tijdschrift voor geneeskunde·2004
Same author

The impact of work-related trauma on the well-being of perioperative nurses.

Collegian (Royal College of Nursing, Australia)·2004
Same author

Work-related trauma: the experiences of perioperative nurses.

Collegian (Royal College of Nursing, Australia)·2004
Same journal

Calcitonin Gene-Related Peptide-Induced Central Sensitization: A Hypothesis for Long COVID Symptoms.

Medical hypotheses·2026
Same journal

Subclinical mastitis during lactation: a modifiable risk factor for breast cancer?

Medical hypotheses·2025
Same journal

The Role of Hemispheric Sensory Shifts: Impacts on Stretch Reflex and Motor Plasticity Post-Stroke.

Medical hypotheses·2025
Same journal

Neuron-Targeted Exosome Therapy: A Novel Approach for Treating Cardiogenic Dementia via RyR2 Inhibition.

Medical hypotheses·2025
Same journal

How the Somatosensory System Adapts to the Motor Change in Stroke: A Hemispheric Shift?

Medical hypotheses·2024
Same journal

Unstable Plaque is a Treatable Cause of Cognitive Decline.

Medical hypotheses·2024
See all related articles

Adrenoceptors in airways may convert between alpha and beta types due to environmental changes during hyperventilation. This conversion could explain airway obstruction in asthma, especially during exercise.

Area of Science:

  • Physiology
  • Pharmacology
  • Respiratory Medicine

Background:

  • Adrenoceptor stability is influenced by environmental factors like temperature, pH, and hormones.
  • Functional conversion between alpha and beta adrenoceptors has been observed in mammalian myocardium.

Purpose of the Study:

  • To hypothesize that adrenoceptors in the respiratory system may undergo similar functional conversion.
  • To explore the potential role of this interconversion in airway obstruction during exercise in asthmatic subjects.

Main Methods:

  • The study proposes a hypothesis based on existing knowledge of adrenoceptor stability.
  • It considers the physiological changes during hyperventilation, such as heat and water loss.
  • It links these changes to potential adrenoceptor function shifts.

Related Experiment Videos

Main Results:

  • Environmental changes during hyperventilation may cause loss of inhibitory beta adrenoceptors and expression of excitatory alpha adrenoceptors in airways.
  • This shift could counteract normal adrenergic homeostatic mechanisms.
  • This mechanism may be particularly relevant for asthmatic individuals.

Conclusions:

  • Adrenoceptor interconversion is a plausible hypothesis for exercise-induced airway obstruction in asthma.
  • Alpha adrenergic antagonists have shown efficacy in preventing exercise-induced asthma, supporting this concept.