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Why geneticists stole cancer research even though cancer is primarily a signaling disease
1Chief Scientific Advisor and Academic Editor, Science Signaling, American Association for the Advancement of Science, Washington, DC 20005, USA. myaffe@mit.edu.
Abstract:
Genetic approaches to cancer research have dramatically advanced our understanding of the pathophysiology of this disease, leading to similar genetics-based approaches for precision therapy, which have been less successful. Reconfiguring and adapting the types of technologies that underlie genetic research to dissect tumor cell signaling in clinical samples may offer an alternative road forward.
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