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Related Experiment Video

Updated: Jan 30, 2026

Assessment of Dictyostelium discoideum Response to Acute Mechanical Stimulation
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Triparental inheritance in Dictyostelium.

Gareth Bloomfield1, Peggy Paschke2, Marina Okamoto3

  • 1Division of Cell Biology, Medical Research Council Laboratory of Molecular Biology, Cambridge Biomedical Campus, Cambridge, CB2 0QH, United Kingdom; garethb@mrc-lmb.cam.ac.uk.

Proceedings of the National Academy of Sciences of the United States of America
|January 24, 2019
PubMed
Summary

Social amoebae exhibit high-frequency genetic recombination during sex, even without the Spo11 enzyme. This process allows for triparental inheritance, where progeny inherit nuclear DNA from two parents and mitochondrial DNA from a third.

Keywords:
meiosismitochondriarecombinationsocial amoebaesyngamy

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Area of Science:

  • Genetics
  • Evolutionary Biology
  • Molecular Biology

Background:

  • Sexual reproduction is widespread in eukaryotes, but its molecular mechanisms are not fully understood in all lineages.
  • Social amoebae like Dictyostelium discoideum engage in a unique form of sex involving cytoplasmic mixing.
  • Studying sexual progeny in D. discoideum has been technically challenging.

Purpose of the Study:

  • To perform a genome-wide characterization of meiotic progeny in Dictyostelium discoideum.
  • To investigate the mechanisms and outcomes of sexual reproduction in this model organism.
  • To explore the role of sex in genetic variation and evolution.

Main Methods:

  • Genome-wide analysis of meiotic progeny from pairwise crosses of Dictyostelium discoideum.
  • Characterization of nuclear haplotype recombination and mitochondrial genome inheritance.
  • Investigation of genetic exchange in the absence of the Spo11 enzyme.

Main Results:

  • High-frequency recombination occurs in pairwise crosses between all three mating types, independent of Spo11.
  • Triparental inheritance is common, resulting in progeny with nuclear DNA from two parents and mitochondrial DNA from a third.
  • Cells not contributing to the zygote nucleus can still influence the next generation.

Conclusions:

  • Dictyostelium discoideum sex facilitates extensive genetic recombination and novel inheritance patterns.
  • The findings suggest a potential role for sexual selection in mitochondrial genome evolution.
  • This unique sexual system may offer insights into eukaryogenesis and the early evolution of sex.