Related Experiment Video
Updated: Jan 30, 2026
10:31
Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
Published on: May 2, 2025
697
Using a Targeted Proteomics Chip to Explore Pathophysiological Pathways for Incident Diabetes- The Malmö Preventive
John Molvin1,2, Manan Pareek3,4, Amra Jujic5
1Department of Clinical Sciences, Lund University, Clinical Research Center, Malmö, Sweden. johnmolvin@gmail.com.
Scientific Reports
|January 24, 2019
Summary
This study identified seven proteins linked to new-onset diabetes, including three novel associations. Two proteins, Galectin-4 and Paraoxonase type 3, showed glucose-independent links to diabetes risk.
Area of Science:
- Biochemistry
- Proteomics
- Endocrinology
Background:
- Multiplex proteomic platforms enable the study of protein associations with diseases like diabetes.
- Understanding these associations can reveal prognostic, diagnostic, and therapeutic targets.
Purpose of the Study:
- To explore novel pathophysiological pathways in incident diabetes.
- To identify proteins associated with the development of diabetes in a population-based cohort.
Main Methods:
- Analysis of 92 proteins in a population-based cohort with 146 incident diabetes cases and 880 controls over 8 years.
- Statistical adjustment for traditional diabetes risk factors.
Main Results:
- Seven proteins were significantly associated with incident diabetes after adjusting for traditional risk factors.
- Four proteins (Scavenger receptor cysteine rich type 1 protein M130, Fatty acid binding protein 4, Plasminogen activator inhibitor 1, Insulin-like growth factor-binding protein 2) had previously established associations.
- Three proteins (Cathepsin D, Galectin-4, Paraoxonase type 3) demonstrated novel associations with incident diabetes.
- Galectin-4 (increased risk) and Paraoxonase type 3 (decreased risk) remained significant after adjusting for plasma glucose, suggesting glucose-independent associations.
Conclusions:
- Novel proteins, including Cathepsin D, Galectin-4, and Paraoxonase type 3, are associated with incident diabetes.
- Galectin-4 and Paraoxonase type 3 exhibit glucose-independent associations with diabetes development, highlighting potential new therapeutic targets.
More Related Videos
15:18Near Infrared Optical Projection Tomography for Assessments of β-cell Mass Distribution in Diabetes Research
Published on: January 12, 2013
16.9K
08:15Author Spotlight: Network Pharmacology and Molecular Docking to Decipher the Action of Jiawei Shengjiang San Against Diabetic Kidney Disease
Published on: May 10, 2024
963
Related Concept Videos
01:20Pathophysiology of Diabetes
3.6K
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
3.6K
01:08Prevalence and Incidence
1.8K
In statistical epidemiology and health sciences, two essential metrics—prevalence and incidence—are fundamental for understanding disease dynamics within a population. These measures enable public health officials, epidemiologists, and researchers to assess the burden of diseases, allocate resources effectively, and design impactful public health policies and interventions.
Prevalence indicates the proportion of individuals in a population who have a specific disease or health...
Prevalence indicates the proportion of individuals in a population who have a specific disease or health...
1.8K
02:18Fischer Projections
16.5K
Learning to draw Fischer projections of molecules and understanding their relevance plays a crucial role in the visual depiction of organic molecules. A Fischer projection is a two-dimensional projection on a planar surface to simplify the three-dimensional wedge–dash representation of molecules. This is especially helpful in the case of molecules with multiple chiral centers that can be difficult to draw. Here, all the bonds of interest are represented as horizontal or vertical lines. While...
16.5K
02:06Newman Projections
20.9K
Different notations are used to represent the three-dimensional structure of molecules on two-dimensional surfaces. One of the most commonly used representations is the dash-wedge formula. The dashed wedges, solid wedges, and the plane lines indicate the groups situated behind the plane, coming out of the plane, and in the plane, respectively.
The organic molecules rotate across the single bonds leading to numerous temporary three-dimensional structures of varying energy known as...
The organic molecules rotate across the single bonds leading to numerous temporary three-dimensional structures of varying energy known as...
20.9K
01:27C4 Pathway and CAM
49.1K
Most plants use the C3 pathway for carbon fixation. However, some plants, such as sugar cane, corn, and cacti that grow in hot conditions, use alternative pathways to fix carbon and conserve energy loss due to photorespiration. Photorespiration is the process that occurs when the oxygen concentration is high. Under such conditions, the rubisco enzyme in the Calvin cycle binds O2 instead of CO2, which halts photosynthesis and consumes energy.
C4 Pathway
The C4 pathway is used by plants such as...
C4 Pathway
The C4 pathway is used by plants such as...
49.1K
01:29Pneumonia II: Pathophysiology
2.9K
The pathophysiology of pneumonia involves the following steps:
2.9K