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[Endocrinological and metabolic disorders in the patients with massive bowel resection in the newborn period]

S Kamagata1, H Ishida, A Hayashi

  • 1Department of Surgery and Pediatrics, Tokyo Metropolitan Kiyose Children's Hospital, Japan.

Nihon Geka Gakkai Zasshi
|September 1, 1988
PubMed

Insights

Massive small bowel resection in newborns can impact growth and glucose metabolism, potentially suppressing insulin secretion. Long-term effects include endocrine and renal issues, highlighting the need for careful monitoring.

Area of Science:

  • Pediatric Surgery
  • Endocrinology
  • Gastroenterology

Background:

  • Massive small bowel resection (70%) was performed in seven neonates.
  • A follow-up study evaluated growth and endocrinological status in four patients.

Observation:

  • Three patients exhibited below the 50th percentile for body weight and height.
  • Glucose tolerance tests revealed low peak insulin (IRI) and subnormal insulinogenic indices.

Findings:

  • Suggests underlying mechanisms suppress insulin secretion post-resection.
  • Pituitary and thyroid functions were normal; however, a 15-year-old boy showed delayed secondary sexual characteristics.
  • Hyperoxaluria was observed in three children, with one developing kidney stones and impaired renal function.

Implications:

  • Highlights potential long-term endocrine and metabolic sequelae of extensive small bowel resection in infants.
  • Underscores the need for comprehensive monitoring of growth, glucose metabolism, and renal function in affected children.
  • Suggests further research into the mechanisms of insulin suppression and potential interventions.

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