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Natural Products Mediated Targeting of Virally Infected Cancer

Iram Fatima1, Sobia Kanwal2, Tariq Mahmood1

  • 1Department of Plant Sciences, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan.

Dose-Response : a Publication of International Hormesis Society
|January 24, 2019
PubMed

Insights

Natural products offer promising treatments for virus-associated cancers. This study explores bioactive compounds from diverse natural sources, including plants and fruits, for their potential in combating these challenging malignancies.

Area of Science:

  • Oncology
  • Virology
  • Pharmacology

Background:

  • Viral infections are linked to several human cancers, particularly in immunocompromised individuals.
  • Eight distinct virus-associated cancers have been identified to date.
  • Understanding the mechanisms of viral oncogenesis is crucial for developing targeted therapies.

Purpose of the Study:

  • To investigate the therapeutic potential of natural products against virus-associated cancers.
  • To identify and review bioactive compounds from natural sources with anticancer properties.
  • To explore the role of cell surface molecules in viral entry and cancer progression.

Main Methods:

  • Literature review of natural products with documented anticancer activity.
  • Analysis of bioactive compounds from plants, marine organisms, insects, microorganisms, fruits, and vegetables.
  • Examination of mechanisms of action for natural anticancer agents.

Main Results:

  • Numerous pharmaceutical agents have been isolated from various natural sources, including vincristine, resveratrol, curcumin, and various marine-derived compounds.
  • Specific compounds like curcumin (turmeric), resveratrol (red grapes), and catechins (green tea) show promise for anticancer therapy.
  • Natural products target diverse pathways involved in cancer development and progression.

Conclusions:

  • Natural products represent a valuable resource for developing novel therapeutic strategies against virus-associated cancers.
  • Bioactive compounds from plants, fruits, and other natural sources offer a promising avenue for cancer treatment.
  • Further research into natural product-derived drugs can lead to more effective and potentially less toxic cancer therapies.
Keywords:
cancercell surface moleculesnatural sourcesvirus

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