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Orthotopic Transplantation of Breast Tumors as Preclinical Models for Breast Cancer
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Orthotopic Transplantation of Breast Tumors as Preclinical Models for Breast Cancer

Published on: May 18, 2020

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Mouse models of breast cancer in preclinical research

Mi Kyung Park1, Chang Hoon Lee2, Ho Lee1,3

  • 1Department of Cancer Biomedical Science, National Cancer Center Graduate School of Cancer Science and Policy, Gyeonggi, Korea.

Laboratory Animal Research
|January 24, 2019
PubMed

Insights

Mouse models are crucial for understanding breast cancer progression and developing new treatments. This review covers transplantation and genetically engineered models for advancing breast cancer research and drug discovery.

Area of Science:

  • Oncology
  • Translational Medicine
  • Cancer Biology

Background:

  • Breast cancer is a leading cause of cancer death in women globally.
  • Diverse subtypes (ER+, PR+, HER2+, TNBC) complicate treatment strategies.
  • Advances in targeted therapies necessitate robust preclinical models.

Purpose of the Study:

  • To review existing mouse models for breast cancer research.
  • To highlight the application of these models in understanding cancer mechanisms and metastasis.
  • To discuss their role in evaluating novel anti-cancer therapeutics.

Main Methods:

  • Summary of tumor transplantation models in breast cancer.
  • Overview of genetically engineered mouse models (GEMMs) for breast cancer.
  • Analysis of model utility in preclinical research and drug development.

Main Results:

  • Mouse models are essential for studying breast cancer progression and metastasis.
  • These models facilitate the investigation of underlying genetic pathways.
  • They aid in developing and testing targeted therapies and treatment strategies.

Conclusions:

  • Tumor transplantation and GEMMs are vital tools in breast cancer research.
  • These models enhance understanding of molecular mechanisms and clinical subtypes.
  • They are instrumental in advancing anti-cancer drug development and therapeutic innovation.
Keywords:
Breast cancergenetically engineered mouse modelstumor transplantation model

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