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Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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Small interfering RNAs, or siRNAs, are short regulatory RNA molecules that can silence genes post-transcriptionally, as well as the transcriptional level in some cases. siRNAs are important for protecting cells against viral infections and silencing transposable genetic elements.
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Regulation of Hematopoietic Stem Cells01:01

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All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
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piRNA - Piwi-interacting RNAs02:57

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PIWI-interacting RNAs, or piRNAs, are the most abundant short non-coding RNAs. More than 20,000 genes have been found in humans that code for piRNAs while only 2000 genes have been found for miRNAs. piRNAs can act at the transcriptional and post-transcriptional levels and have a vital role in silencing transposable elements present in germ cells. They are also involved in epigenetic silencing and activation. Previously, they were thought to function only in germ cells but new evidence suggests...
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Epigenetic Regulation01:46

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Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
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Long non-coding RNAs in hematopoietic regulation.

Weiqian Li1,2, Yue Ren1,2, Yanmin Si1,2

  • 1State Key Laboratory of Medical Molecular Biology, Department of Biochemistry & Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS), Peking Union Medical College (PUMC), Beijing, 100005, China.

Cell Regeneration (London, England)
|January 24, 2019
PubMed
Summary

Long non-coding RNAs (lncRNAs) are vital regulators in blood cell development. Their dysregulation is linked to various diseases, impacting patient outcomes.

Keywords:
HematopoiesisLeukemialncRNAs

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Area of Science:

  • Molecular Biology
  • Genetics
  • Developmental Biology

Background:

  • Long non-coding RNAs (lncRNAs) are key regulators in cellular processes.
  • lncRNA interactions with DNA, RNA, and proteins influence gene expression.
  • lncRNAs play significant roles in the development of blood cells (hematopoiesis).

Purpose of the Study:

  • To review the functions of lncRNAs in normal hematopoietic development.
  • To explore the connection between lncRNA dysregulation and disease phenotypes and prognoses.

Main Methods:

  • Literature review of studies on lncRNAs in hematopoiesis.
  • Analysis of lncRNA regulatory mechanisms.
  • Correlation of lncRNA alterations with hematopoietic disorders.

Main Results:

  • lncRNAs are essential for orchestrating gene regulatory networks in hematopoiesis.
  • Specific lncRNAs act as critical modulators during blood cell differentiation.
  • Altered lncRNA expression patterns are associated with specific hematological diseases.

Conclusions:

  • lncRNAs are fundamental to maintaining normal hematopoietic development.
  • Understanding lncRNA roles offers insights into disease mechanisms and potential therapeutic targets.