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Neuroendocrinology of pyridoxine deficiency
K Dakshinamurti1, C S Paulose, M Viswanathan
1Department of Biochemistry, Faculty of Medicine, University of Manitoba, Winnipeg, Canada.
Neuroscience and Biobehavioral Reviews
|January 1, 1988
Abstract:
Dihydroxyphenylalanine decarboxylase and 5-hydroxytryptophan decarboxylase respectively have high and low affinities for pyridoxal phosphate. In the pyridoxine-deficient animal, hypothalamic serotonin content is significantly reduced without any change in catecholamine levels. Hypothalamic neurotransmitters affect the hypothalamo-pituitary-end organ axes. Specifically, the decrease in hypothalamic serotonin in the pyridoxine-deficient rat results in tertiary hypothyroidism. In addition, pineal function is affected in deficient animals due to decreased synthesis of melatonin.