Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Carbon monoxide studies at high altitude.

J J McGrath1

  • 1Department of Physiology, School of Medicine, Texas Tech University Health Sciences Center, Lubbock 79430.

Neuroscience and Biobehavioral Reviews
|January 1, 1988
PubMed
Summary

High altitude exposure increases carbon monoxide (CO) levels. Studies show 100 ppm CO does not worsen physiological effects of simulated high altitude in rats.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The cost of mental disorders: a systematic review.

Epidemiology and psychiatric sciences·2020
Same author

Comorbidity within mental disorders: a comprehensive analysis based on 145 990 survey respondents from 27 countries.

Epidemiology and psychiatric sciences·2020
Same author

Disentangling schizophrenia spectrum disorders.

Acta psychiatrica Scandinavica·2018
Same author

Smokin' hot: adolescent smoking and the risk of psychosis.

Acta psychiatrica Scandinavica·2018
Same author

Psychotic experiences and religiosity: data from the WHO World Mental Health Surveys.

Acta psychiatrica Scandinavica·2018
Same author

Dopamine, psychosis and schizophrenia: the widening gap between basic and clinical neuroscience.

Translational psychiatry·2018

Area of Science:

  • Environmental Health
  • Physiology
  • Altitude Medicine

Background:

  • Rising ambient carbon monoxide (CO) concentrations in high altitude areas due to increased human activity.
  • Limited research on the acute and chronic physiological impacts of CO inhalation at high altitudes.
  • Existing data suggest additive or synergistic effects of CO and high altitude exposure on human physiology.

Purpose of the Study:

  • To investigate the combined physiological effects of carbon monoxide (CO) and simulated high altitude (SHA) exposure.
  • To determine if CO exacerbates the known physiological impacts of SHA.
  • To assess the effects of SHA and CO on hematocrit ratio, body weight, and cardiac ventricle weights in rats.

Main Methods:

  • Male laboratory rats were exposed for 6 weeks to 100 ppm CO, 4676 m simulated high altitude (SHA), or both.
  • Measurements included hematocrit ratio (Hct), body weight, and right and left ventricle weights.
  • Control groups were not explicitly mentioned but implied through comparative analysis.

Main Results:

  • SHA exposure increased Hct and right ventricle weight, while decreasing body weight.
  • CO exposure alone increased Hct and left ventricle weight.
  • Combined exposure to 100 ppm CO and SHA did not result in exacerbated physiological effects compared to SHA alone.

Conclusions:

  • Exposure to 100 ppm CO does not appear to worsen the physiological adaptations or adverse effects associated with 4676 m simulated high altitude in male rats.
  • The study provides evidence against CO exacerbating SHA effects under these experimental conditions.
  • Further research is warranted to fully understand the complex interactions between CO and high altitude physiology in humans.

Related Experiment Videos