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Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus MRSA
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Ultrasound affects minimal inhibitory concentration of ampicillin against methicillin resistant Staphylococcus aureus

Laura Selan1, Rosanna Papa1, Gaetano Barbato2

  • 1Department of Public Health and Infectious Diseases, Sapienza University, Piazzale Aldo Moro 5, 00185 Rome, Italy.

The New Microbiologica
|January 24, 2019
PubMed

Insights

Novel strategies are needed to combat antimicrobial resistance. This study shows that ultrasound can enhance antibiotic effectiveness, reducing the required ampicillin dosage against bacteria.

Area of Science:

  • Microbiology
  • Biophysics
  • Pharmacology

Background:

  • Antimicrobial resistance (AMR) poses a significant global health threat, necessitating innovative approaches to combat bacterial infections.
  • The increasing prevalence of drug-resistant bacteria highlights the urgent need for strategies to enhance existing antibiotic efficacy.

Purpose of the Study:

  • To investigate the potential of ultrasound as an adjunct therapy to improve antibiotic effectiveness against bacteria.
  • To determine if ultrasound can reduce the dosage of ampicillin required to inhibit bacterial growth and viability.

Main Methods:

  • Utilizing ultrasound in conjunction with ampicillin treatment on bacterial cultures.
  • Quantifying the impact of combined ultrasound and ampicillin on bacterial viability compared to ampicillin alone.

Main Results:

  • Ultrasound significantly enhanced the antimicrobial activity of ampicillin.
  • A reduced dosage of ampicillin was sufficient to impair bacterial viability when combined with ultrasound treatment.

Conclusions:

  • Ultrasound presents a promising strategy for potentiating antibiotic efficacy.
  • This approach could lead to lower antibiotic dosages, potentially mitigating side effects and combating antimicrobial resistance.
Keywords:
MRSAampicillinantimicrobialsonowellultrasound

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