Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chromosome Replication02:31

Chromosome Replication

10.6K
Before a cell can divide, it must accurately replicate all of its chromosomes, including the DNA and its associated histone and non-histone proteins.  This process begins at numerous origins of replication during the S phase of the cell cycle in each of a cell’s chromosomes simultaneously. Certain nucleotides can act as origins of replication, but these sequences are not well defined - especially in complex, multi-cellular, eukaryotic species. The length of DNA that spans an origin...
10.6K
DNA Replication02:40

DNA Replication

59.2K
DNA replication involves the separation of the two strands of the double helix, with each strand serving as a template from which the new complementary strand is copied.  After replication, each double-stranded DNA includes one parental or “old” strand and one “new” strand. This is known as semiconservative replication. The resulting DNA molecules have the same sequence and are divided equally into the two daughter cells.
Replication in Prokaryotes
DNA replication...
59.2K
Replication in Prokaryotes02:35

Replication in Prokaryotes

97.9K
Overview
97.9K
Replication in Eukaryotes02:31

Replication in Eukaryotes

204.7K
Overview
204.7K
Understanding the Self01:28

Understanding the Self

286
The self is a central aspect of human identity, encompassing an individual’s beliefs, emotions, perceptions, and experiences. It is a cognitive and psychological construct that enables individuals to interpret their traits and behaviors, influencing how they perceive themselves and interact with the world. While personality consists of stable and enduring characteristics, the self is shaped by self-perception and social experiences. This distinction highlights the dynamic nature of the...
286
The DNA Replication Fork01:02

The DNA Replication Fork

40.9K
An organism’s genome needs to be duplicated in an efficient and error-free manner for its growth and survival. The replication fork is a Y-shaped active region where two strands of DNA are separated and replicated continuously. The coupling of DNA unzipping and complementary strand synthesis is a characteristic feature of a replication fork.   Organisms with small circular DNA, such as E. coli, often have a single origin of replication; therefore, they have only two replication...
40.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Spatial variation of asthma rates in Los Angeles County by environmental and socioeconomic indicators.

Environmental health : a global access science source·2026
Same author

Spatial analysis of residential location at birth, PFAS in public water, and childhood cancers in Southern California (2000-2019).

Journal of exposure science & environmental epidemiology·2026
Same author

Prenatal and Early Postnatal Lead Exposure and Later Adulthood Cognitive Function in the St. Louis Baby Tooth-Later Life Health Study.

Neurology·2026
Same author

Polyfluoroalkyl substances and altered glucose homeostasis in adolescents following bariatric surgery.

Environmental endocrinology (Oxford, England)·2026
Same author

Evaluation of a mother-child dyad toxicokinetic model paired with environmental doses for estimation of serum per- and polyfluoroalkyl substances in early life.

Environment international·2026
Same author

Associations between per- and polyfluoroalkyl substances and metabolic dysfunction-associated steatotic liver disease in adolescents and young adults: modifying roles of age, lifestyle factors, and PNPLA3 genotype.

Environmental research·2025

Related Experiment Video

Updated: Jan 30, 2026

Environmental Modulations of the Number of Midbrain Dopamine Neurons in Adult Mice
09:35

Environmental Modulations of the Number of Midbrain Dopamine Neurons in Adult Mice

Published on: January 20, 2015

9.3K

Understanding and Mitigating the Replication Crisis, for Environmental Epidemiologists.

Scott M Bartell1,2,3

  • 1Program in Public Health, Susan and Henry Samueli College of Health Sciences, University of California Irvine, 2032 Anteater Instruction & Research Building, Irvine, CA, 92697-3957, USA. sbartell@uci.edu.

Current Environmental Health Reports
|January 24, 2019
PubMed
Summary

Most scientific findings are not reproducible due to underpowered studies and rare true associations. Improving study design, statistical rigor, and bias control is crucial for reliable environmental epidemiology research.

Keywords:
False discovery rateFalse positiveFamily-wise error rateHypothesis testingReliabilityReproducibilityType I errorp value

More Related Videos

Ecotoxicological Method with Marine Bacteria Vibrio anguillarum to Evaluate the Acute Toxicity of Environmental Contaminants
11:26

Ecotoxicological Method with Marine Bacteria Vibrio anguillarum to Evaluate the Acute Toxicity of Environmental Contaminants

Published on: May 26, 2017

11.6K
Bioprospecting of Extremophilic Microorganisms to Address Environmental Pollution
07:20

Bioprospecting of Extremophilic Microorganisms to Address Environmental Pollution

Published on: December 30, 2021

4.2K

Related Experiment Videos

Last Updated: Jan 30, 2026

Environmental Modulations of the Number of Midbrain Dopamine Neurons in Adult Mice
09:35

Environmental Modulations of the Number of Midbrain Dopamine Neurons in Adult Mice

Published on: January 20, 2015

9.3K
Ecotoxicological Method with Marine Bacteria Vibrio anguillarum to Evaluate the Acute Toxicity of Environmental Contaminants
11:26

Ecotoxicological Method with Marine Bacteria Vibrio anguillarum to Evaluate the Acute Toxicity of Environmental Contaminants

Published on: May 26, 2017

11.6K
Bioprospecting of Extremophilic Microorganisms to Address Environmental Pollution
07:20

Bioprospecting of Extremophilic Microorganisms to Address Environmental Pollution

Published on: December 30, 2021

4.2K

Area of Science:

  • Environmental epidemiology
  • Scientific reproducibility

Background:

  • Many published research findings are unreproducible across various scientific fields.
  • Lack of reproducibility poses a significant challenge to scientific advancement.

Purpose of the Study:

  • To review factors contributing to the lack of reproducibility in scientific findings.
  • To evaluate the implications for environmental epidemiology.
  • To propose strategies for mitigating reproducibility issues.

Main Methods:

  • Literature review evaluating factors influencing reproducibility.
  • Analysis of implications for environmental epidemiology.
  • Synthesis of mitigation strategies.

Main Results:

  • Underpowered analyses and low prevalence of true associations are primary causes of irreproducibility.
  • Publication bias and selective reporting also contribute.
  • New trends in environmental epidemiology may exacerbate reproducibility challenges without mitigation.

Conclusions:

  • Environmental epidemiologists must enhance study power, focus on justified hypotheses, and control statistical errors.
  • Emphasis on estimation over statistical significance and bias analysis is recommended.
  • Careful study design, analysis, and interpretation are essential to counteract spurious findings and improve reproducibility.