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Dead-end (dnd) protein in fish-a review
Abdul Rasheed Baloch1, Roman Franěk2, Taiju Saito2,3
1South Bohemian Research Center for Aquaculture and Biodiversity of Hydrocenoses, Research Institute of Fish Culture and Hydrobiology, Faculty of Fisheries and Protection of Waters, University of South Bohemia in Ceske Budejovice, Zatisi 728/II, 389 25, Vodnany, Czech Republic. baloch@frov.jcu.cz.
Fish Physiology and Biochemistry
|January 24, 2019
Summary
Dead end (dnd) protein is crucial for primordial germ cell (PGC) migration and function in vertebrates. Targeting dnd in fish offers a method for controlling PGCs, impacting fertility and sex differentiation.
Area of Science:
- Developmental biology
- Genetics
- Reproductive biology
Background:
- Dead end (dnd) is a germ plasm-specific maternal RNA found in vertebrates.
- Dnd protein is vital for primordial germ cell (PGC) migration and motility.
- PGCs must migrate to gonads for fertility, and disruptions impact reproduction.
Purpose of the Study:
- To review the role of dnd in germ cell development and function.
- To explore dnd as a molecular marker in fish.
- To discuss dnd's interaction with miRNAs and its applications.
Main Methods:
- Literature review on dnd's function in PGCs.
- Analysis of dnd's role in zebrafish and other fish species.
- Examination of dnd's impact on PGC survival, migration, and transdifferentiation.
Main Results:
- Dnd is essential for PGC migration but not survival.
- Dnd-deficient PGCs can transdifferentiate into somatic cells.
- Targeting dnd in fish leads to PGC removal, affecting sex differentiation and causing sterility.
Conclusions:
- Dnd is a key regulator of PGCs in fish.
- Dnd's function extends beyond PGC migration to influence sex differentiation.
- Dnd has potential applications in aquaculture and fish conservation through targeted manipulation.
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