Related Experiment Video
Updated: Jan 30, 2026
Evidence for EpCAM and Cytokeratin Expressing Epithelial Cells in Normal Human and Murine Blood and Bone Marrow
Published on: April 21, 2023
Nutrients and Nutraceuticals for the Management of High Normal Blood Pressure: An Evidence-Based Consensus Document
Arrigo F G Cicero1, Davide Grassi2, Giuliano Tocci3,4
1Medical and Surgical Sciences Dept, Sant'Orsola-Malpighi University Hospital, U.O. Medicina Interna Borghi, Via Albertoni, 15, 40138, Bologna, Italy. arrigo.cicero@unibo.it.
Insights
Nutrients and nutraceuticals show promise in managing hypertension and preventing cardiovascular issues. These interventions can help lower blood pressure and reduce disease burden, complementing traditional treatments.
Area of Science:
- Cardiovascular Medicine
- Nutritional Science
- Preventive Cardiology
Background:
- Essential hypertension is a leading cardiovascular risk factor globally, contributing significantly to disease burden.
- Despite available treatments, blood pressure (BP) control rates remain low, increasing hypertension-related costs and disabilities.
- Preventive strategies are crucial for improving BP control and reducing high-normal BP levels.
Purpose of the Study:
- To systematically analyze the evidence for nutrients and nutraceuticals in hypertension management.
- To evaluate their role in individuals with high-normal BP and varying cardiovascular risk profiles.
- To explore their potential as adjuncts to pharmacological and non-pharmacological interventions.
Main Methods:
- Systematic review and critical analysis of existing scientific literature.
- Focus on evidence supporting the use of nutrients and nutraceuticals.
- Assessment of effects on blood pressure levels and disease progression.
Main Results:
- Nutrients and nutraceuticals demonstrate favorable effects in hypertension management and control.
- These interventions can effectively and safely reduce BP levels towards therapeutic targets.
- They show potential in preventing disease progression from high-normal BP to stage 1 hypertension.
Conclusions:
- Nutrients and nutraceuticals represent a valuable addition to hypertension management strategies.
- Their use can improve BP control rates and reduce the global burden of hypertension-related diseases.
- Further research and application are warranted for individuals with high-normal BP across different risk strata.
Abstract:
Essential hypertension still represents the most common cardiovascular risk factor, which is responsible for the vast majority of global burden of disease, worldwide. Antihypertensive treatment aimed at lowering blood pressure (BP) levels to the recommended therapeutic targets has demonstrated to reduce risk of developing major cardiovascular, cerebrovascular and renal complications. Despite these evidence, overall rates of BP control are dramatically low in most European and Western countries, as well as in the so called developing countries, thus contributing to the increasingly amount of hypertension-related costs and disabilities. For these reasons, preventive strategies aimed at improving BP control rates in treated hypertensive patients and reducing high-normal BP levels in asymptomatic otherwise healthy individuals may contribute to reduce the burden of disease related to hypertension. In this view, an extensive use of nutrients and nutraceuticals has demonstrated to provide favorable effects in hypertension management and control, beyond the adoption of pharmacological and non-pharmacological interventions. These interventions can effectively and safely reduce BP levels to targets and prevent disease progression form high-normal BP levels towards stage 1 hypertension. The present consensus document will systematically describe and critically analyze the currently available evidence in favor of the use of nutrients and nutraceuticals in those individuals with high-normal BP levels at different cardiovascular risk profile.
Related Concept Videos
01:15Methods of Documentation VI: Case Management Model
For example, a patient with a chronic...
02:55The Evidence for Evolution
01:24Blood Pressure
01:30Blood Pressure
The average BP in an adult is typically around 120/80 mmHg (millimeters of mercury). In this measurement, the numerator (120) indicates the systolic pressure, which is the pressure in the arteries during the contraction of the heart's ventricles as blood is expelled. The denominator (80) represents the...
01:17Measurement of Blood Pressure
01:28Factors affecting Blood pressure
Physiological Factors: