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Updated: Jan 30, 2026

A Proteoliposome-Based Efflux Assay to Determine Single-molecule Properties of Cl- Channels and Transporters
Published on: April 20, 2015
Active transport in a channel: stabilisation by flow or thermodynamics
Santhan Chandragiri1, Amin Doostmohammadi, Julia M Yeomans
1Department of Chemical Engineering, Indian Institute of Technology Madras, Chennai 600036, India. sumesh@iitm.ac.in.
Active fluids in channels can create self-sustained flows. Simulations reveal flow states depend on channel width, vortex size, and material properties like flow aligning or tumbling.
Area of Science:
- Physics
- Materials Science
- Fluid Dynamics
Background:
- Active materials like bacterial suspensions show potential for self-sustained flows.
- Understanding active systems in confined channels is crucial for developing active microfluidics.
Purpose of the Study:
- To investigate the behavior of active fluids confined within a two-dimensional channel using continuum simulations.
- To explore how active flow induces nematic order in systems lacking passive ordering.
Main Methods:
- Continuum simulations were employed to model active fluids in a 2D channel.
- The study focused on conditions where passive systems exhibit no nematic order.
- Systematic analysis identified stable flow states and generated a phase diagram.
Main Results:
- Several distinct stable flow states were identified within the confined channel.
- The study determined key parameters controlling flow behavior.
- Nematic order was shown to be induced by the active flow itself.
Conclusions:
- The ratio of channel width to active flow vortex length scale is a critical factor.
- Whether the active fluid is flow aligning or flow tumbling significantly influences flow states.
- These findings provide insights into designing and controlling active microfluidic systems.
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