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Displacement Current01:19

Displacement Current

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Ampère's law, in its usual form, does not work in places where the current changes with time and is not steady. Thus, Maxwell suggested including an additional contribution, called the displacement current, Id, to the real conduction current I.
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Position and Displacement01:31

Position and Displacement

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The position of an object defines its location relative to a convenient frame of reference at any particular time. A frame of reference is an arbitrary set of axes from which the position and motion of an object are described. Earth is often used as a frame of reference, and we often describe the position of an object as it relates to stationary objects on Earth. For example, a rocket launch could be described in terms of the position of the rocket with respect to Earth as a whole. On the other...
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Position and Displacement Vectors01:00

Position and Displacement Vectors

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To describe the motion of an object, one should first be able to describe its position (where it is at any particular time). More precisely, the position needs to be specified relative to a convenient frame of reference. A frame of reference is an arbitrary set of axes from which the position and motion of an object are described. Earth is often used as a frame of reference to describe the position of an object in relation to stationary objects on Earth.
Further, several important kinds of...
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Significance of Displacement Current01:27

Significance of Displacement Current

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A displacement current is analogous to a real current in Ampère's law, participating in Ampère's law the same way as the usual conduction current. However, it is produced by a changing electric field. Displacement current is defined in terms of a time-varying electric field, and also has an associated displacement current density. By adding a term accounting for displacement current, Maxwell modified the existing Ampère's law, which is now called generalized Ampère's law.
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Angular Velocity and Displacement01:08

Angular Velocity and Displacement

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Uniform circular motion is motion in a circle at a constant speed. Although this is the simplest case of rotational motion, it is very useful for many situations and is used to introduce rotational variables. When a particle is moving in a circle, the coordinate system is fixed and serves as a frame of reference to define the particle’s position. Its position vector from the origin of the circle to the particle sweeps out the angle θ, which increases in the counterclockwise direction...
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Lateralization01:28

Lateralization

1.0K
Brain lateralization refers to the division of mental processes and functions between the two hemispheres of the brain, a phenomenon that optimizes neural efficiency and underpins complex abilities in humans. This specialization allows each hemisphere to perform tasks where it has a comparative advantage, facilitating more refined cognitive capabilities across different domains.
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Related Experiment Video

Updated: Jan 30, 2026

Pneumatically Driven Microfluidic Platform for Micro-Particle Concentration
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Pneumatically Driven Microfluidic Platform for Micro-Particle Concentration

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Degas-Driven Deterministic Lateral Displacement in Poly(dimethylsiloxane) Microfluidic Devices.

Naotomo Tottori1, Takasi Nisisako2

  • 1Department of Mechanical Engineering , School of Engineering, Tokyo Institute of Technology , Tokyo 152-8552 , Japan.

Analytical Chemistry
|January 24, 2019
PubMed
Summary
This summary is machine-generated.

Degas-driven microfluidic devices using deterministic lateral displacement effectively separate and enrich particles by size. This technology shows high purity for separating microparticles and blood cells, demonstrating its potential in various applications.

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Area of Science:

  • Microfluidics
  • Biotechnology
  • Materials Science

Background:

  • Microfluidic devices offer precise control over fluid dynamics.
  • Deterministic lateral displacement (DLD) is a label-free separation technique.
  • Poly(dimethylsiloxane) (PDMS) is a common material for microfluidic fabrication.

Purpose of the Study:

  • To fabricate and evaluate degas-driven microfluidic deterministic lateral displacement (DLD) devices.
  • To demonstrate particle enrichment and size-based separation using DLD.
  • To assess the device's capability for separating biological cells.

Main Methods:

  • Fabrication of PDMS-based microfluidic devices with DLD arrays.
  • Utilized degas-driven flow for particle manipulation.
  • Employed single-input and sheath-input configurations for enrichment and separation.
  • Tested with fluorescent polymer particles (7 and 13 μm) and whole blood samples.

Main Results:

  • Selective enrichment of 13 μm particles from a mixture with 7 μm particles was achieved.
  • High purity separation of 7 μm and 13 μm beads (>92.62% and >99.98%).
  • Fractionation of 7 μm bead clusters based on equivalent size.
  • Successful separation of white blood cells from red blood cells with 95.57% capture efficiency and 86.97% purity.

Conclusions:

  • Degas-driven microfluidic DLD devices are effective for particle enrichment and size-based separation.
  • The demonstrated purity and efficiency highlight the potential for biological sample processing.
  • This technology offers a promising platform for microparticle manipulation and cell separation applications.