Related Experiment Video
Updated: Jan 30, 2026

A Protocol to Set Up Needle-Free Connector with Positive Displacement on Central Venous Catheter in Intensive Care Unit
Published on: July 13, 2019
Risk factors for vascular catheter-related bloodstream infections in pediatric intensive care units
Fabiola Peixoto Ferreira La Torre1, Gabriel Baldanzi2, Eduardo Juan Troster3,4
1Departamento de Pediatria, Faculdade de Ciências Médicas, Santa Casa de São Paulo - São Paulo (SP), Brasil.
Insights
Prolonged central venous catheter use and multiple catheter insertions increase the risk of central line-associated blood stream infections (CLABSI) in pediatric intensive care units. These findings highlight key factors for preventing CLABSI in critically ill children.
Area of Science:
- Pediatric Intensive Care
- Infectious Diseases
- Epidemiology
Background:
- Central line-associated blood stream infections (CLABSI) are a significant concern in pediatric intensive care units (PICUs).
- Understanding risk factors is crucial for developing effective prevention strategies.
Purpose of the Study:
- To identify risk factors for CLABSI in PICUs.
- To determine the incidence and causes of CLABSI in PICUs with varying characteristics.
Main Methods:
- Prospective cohort study involving 728 patients across three different hospital types.
- Included patients aged 1 month to 18 years with central venous catheters for over 24 hours.
- Data analyzed using SPSS version 13.0 to compare patients with and without CLABSI.
Main Results:
- CLABSI incidence rate was 3.9 per 1000 central venous catheter-days, varying by hospital.
- Independent risk factors for CLABSI included longer central venous catheter duration (OR: 1.07) and use of multiple catheters (OR: 2.59).
- Mortality rate was 11.1%, with a higher rate in CLABSI patients (12.9%).
Conclusions:
- Extended use of central venous catheters is a primary risk factor for CLABSI in PICUs.
- Utilizing more than one central venous catheter concurrently significantly elevates CLABSI risk.
- These findings underscore the importance of judicious catheter use in pediatric critical care settings.
Objectives:
To determine the risk factors for acquiring central line-associated blood stream infections (CLABSI) in pediatric intensive care units and to investigate the incidence and etiology of CLABSI in pediatric intensive care units with different profiles.
Methods:
The study was a prospective cohort study in three hospitals. One of the hospitals is a large metropolitan public hospital with two pediatric intensive care units and a total of nineteen pediatric intensive care unit beds, another is a regional hospital with eight pediatric intensive care unit beds, and the third is a private hospital with fifteen beds. Patients between the ages of 1 month old and 18 years old who used a central venous catheter for over 24 hours were included. We recorded patients' daily progress. General patient and catheter-related data were collected and used as variables. All the data were analyzed using Statistical Package for Social Science (SPSS), version 13.0, to compare patients with CLABSI with or without risk factors.
Results:
A total of 728 patients were admitted to the pediatric intensive care units, and 170 had a central line in place for at least 24 hours. The median age was 32 months, and 97 (57%) of the patients were males. The CLABSI incidence rate was 3.9/1000 central venous catheter-days. The incidence among hospitals varied from 1.6 to 6.6. The overall mortality rate was 11.1%, and the CLABSI and non-CLABSI mortality rates were 12.9% and 10.7%, respectively. In multivariate analysis, independent risk factors for CLABSI were a longer duration of central venous catheter use (OR: 1.07; 95%CI 1.00 - 1.14; p = 0.019) and the use of more than one central venous catheter at once (OR: 2.59; 95%CI 1.17 - 5.73; p = 0.048).
Conclusion:
A longer duration of central venous catheter use and the use of more than one central venous catheter at once were the main risk factors for CLABSI in pediatric intensive care units.
Related Concept Videos
Factors Affecting the Risk of Infection
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
Measurement: Derived Units
Measurement: Standard Units
Urinary Tract Infection III: Diagnostic Studies and Interprofessional Care
Relative Risk
Sound Intensity

