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Pruritus in Patients Under Targeted Anticancer Therapy: A Multidimensional Analysis Using the 5-D Itch Scale
Soo Ick Cho1, Jaewon Lee, Jin Lim
1Department of Dermatology, Seoul National University Hospital, Seoul, Korea.
Acta Dermato-Venereologica
|January 24, 2019
Summary
Patients receiving targeted anticancer therapy, especially epidermal growth factor receptor inhibitors (EGFRIs), frequently experience severe pruritus. This itching is often long-lasting, intense, and disrupts sleep.
Area of Science:
- Oncology
- Dermatology
- Pharmacology
Background:
- Pruritus is a common side effect of targeted anticancer therapies.
- The specific characteristics of pruritus related to different targeted agents remain poorly understood.
Purpose of the Study:
- To investigate and characterize pruritus induced by targeted anticancer agents.
- To identify differences in pruritus based on the type of targeted therapy used.
Main Methods:
- A questionnaire-based survey was administered to cancer patients undergoing targeted therapy.
- Medical records were reviewed to supplement survey data.
- Data collected from 374 cancer patients, including 108 on targeted therapy.
Main Results:
- Out of 205 patients with pruritus, 66 were on targeted therapy.
- Epidermal growth factor receptor inhibitor (EGFRIs) users exhibited the highest prevalence and severity of itching (Numeric Rating Scale, 5-D itch score).
- EGFRIs were associated with frequent, long-lasting, intense itching impacting sleep and localized to specific body sites.
Conclusions:
- Patients treated with EGFRIs frequently experience severe pruritus.
- EGFRIs-induced pruritus significantly impacts patient quality of life, including sleep.
- Further research into managing EG FRI-induced pruritus is warranted.
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