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Interfacial Behavior of Fumonisin B1 Toxin and Its Degradation on the Membrane

Shiv K Sharma1, Sijan Poudel Sharma2, Darlene Miller3

  • 1Department of Chemistry , University of Miami , 1301 Memorial Drive , Coral Gables , Florida 33146 , United States.

Langmuir : the ACS Journal of Surfaces and Colloids
|January 24, 2019
PubMed

Insights

Green LED light degrades Fumonisin B1 (FB1), a mycotoxin causing fungal infections. This study observed FB1 degradation on a Langmuir monolayer, revealing potential therapeutic applications for fungal infections.

Area of Science:

  • Mycology
  • Biochemistry
  • Materials Science

Background:

  • Fumonisin B1 (FB1) is a prevalent mycotoxin associated with fungal infections.
  • Understanding FB1's molecular behavior is crucial for developing effective countermeasures.
  • FB1's interaction with biological tissues, like the cornea, requires detailed investigation.

Purpose of the Study:

  • To investigate the surface chemistry and spectroscopic properties of Fumonisin B1 (FB1).
  • To examine the effect of green LED light irradiation on an FB1 Langmuir monolayer.
  • To correlate interfacial behavior with bulk phase properties of FB1.

Main Methods:

  • Formation and characterization of FB1 Langmuir monolayers.
  • Surface chemistry and spectroscopic analysis of the monolayer.
  • Irradiation studies using green LED light on the monolayer and bulk FB1.

Main Results:

  • FB1 molecules self-assemble into a Langmuir monolayer, mimicking corneal tissue interactions.
  • Green LED light irradiation induced degradation of FB1 within the Langmuir monolayer.
  • Degradation was confirmed by comparing interfacial and bulk phase observations, indicating FB1's reduced stability.

Conclusions:

  • FB1 exhibits self-assembly properties forming a Langmuir monolayer relevant to biological interactions.
  • Green LED light effectively degrades FB1 at the interface and in the bulk phase.
  • This photolytic degradation suggests potential for light-based therapeutic strategies against FB1-associated fungal infections.

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