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Updated: Jan 30, 2026

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Regulat-INGs in tumors and diseases: Focus on ncRNAs

Marjorie Gournay1, Mathieu Paineau2, Jérôme Archambeau2

  • 1INSERM U1242, Chemistry Oncogenesis Stress and Signaling, CLCC Eugène Marquis, Rennes, France; Université de Rennes 1, Rennes, France; Present address: CHU Pontchaillou, Rennes, France.

Cancer Letters
|January 24, 2019
PubMed

Insights

ING family genes are crucial tumor suppressors. This review explores how microRNAs (miRNAs) regulate ING genes, offering insights into cancer and potential targeted therapies.

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • ING family genes function as tumor suppressors, vital for cell homeostasis.
  • Loss or diminished expression of ING genes is observed in numerous cancers and diseases.
  • Mechanisms regulating ING gene expression in oncogenesis require further elucidation.

Purpose of the Study:

  • To review regulatory mechanisms of ING family genes at RNA and protein levels.
  • To focus on the interactions between ING genes and non-coding RNAs (ncRNAs), particularly microRNAs (miRNAs).
  • To highlight the role of miRNA-mediated post-transcriptional regulation in ING gene function.

Main Methods:

  • Literature review summarizing existing research on ING gene regulation.
  • Analysis of studies detailing interactions between ING family members and ncRNAs.
  • Examination of post-transcriptional regulatory mechanisms involving miRNAs and mRNAs.

Main Results:

  • miRNAs are key regulators of post-transcriptional gene expression.
  • Specific interactions between miRNAs and ING family genes have been identified in various diseases, including cancer.
  • These interactions influence ING gene expression and cellular processes.

Conclusions:

  • miRNA-mediated regulation of ING family genes represents a significant area for further investigation.
  • Understanding these interactions can lead to novel therapeutic strategies for cancers and other diseases.
  • Targeted therapies modulating miRNA-ING gene interactions hold promise for future clinical applications.
Keywords:
CancerCaretakerGatekeeperlncRNAmiRNA

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